1894.] produced on Liver Cells by various Compounds. 433 



Action of Nitric Acid on a Fed Liver. 



A. Last food 7 hrs. 45 rains, before death. 



Rectal injection of 0'5 c.c. of nitric acid diluted with 10 c.c. of water 

 (sp. gr. 1011 to 1012) 50 mins. before death. 



B. Liver medium size, quite healthy. 



Cells large, swollen looking. 



Miloma and outline of cells very clear, normal. 



Meshes of mitoma large round the nucleus (normal). 



Bile canaliculi indi?*inct. 



Glycogen very slightly increased. 



Sugar formed in 24 hrs. post mort., normal amount. 



Iron reaction much less than normal. 



C. This action resembles closely that of pilocarpine. 



Action of Aniline on a Starved Liver. 



A. This experiment is not quite comparable with the others. A 

 rabbit, after being treated in the usual way, received an injection of 



gram of acetate of ammonium per rectum, and 20 mins. afterwards 

 another 1*5 gram. This apparently produced no effect, and the rabbit 

 was not killed. It was then fed 42 hrs. before its death ; f hr. before 

 it was killed, 1 gram of aniline thoroughly mixed with water was 

 injected into the rectum. This produced well-marked symptoms, as 

 in XXIII. 



B. There were few psorospermic lesions, the liver was very small. 

 Cells unequal ; some small, some medium size. 

 Mitoma and outlines of cells indistinct generally, but distinct at 

 ilaces. 



Meshes generally small. 



Main bile canaliculi distinct in the portal zone. 

 Glycogen reaction indistinct, diffuse. 

 Sugar produced in 24 hrs. post mart., very small. 

 Iron reaction considerably increased. 



C. The secretory activity of the liver did not seem to be much 

 affected by aniline, but this substance seems to have had destructive 

 action on some cells, and has caused a considerable splitting of 

 organic compounds containing iron. In certain parts the cells were 

 dropsical and possibly necrosed. 



Action of' Aniline on a Fasting Liver. 



A. Last meal 25 hrs. before death. 



1 gram (15'5 grains) of pure aniline mixed with 10 c.c. of water 

 injected into the rectum 1 hr. 32 mins. before death. 



