1894.] produced on Liver Cells by various Compounds. 435 



Sugar obtained in 24 hrs. post mort., a little more than half the 

 normal amount. 



Iron reaction considerably increased. 



C. Phenol in this case evidently interfered with constructive meta- 

 bolism, and caused an increased decomposition of organic compounds 

 containing iron. 



Note. In this case there were also evidences of beginning necrosis 

 of patches of liver cells. 



Action of Atropine on a Fed Liver. 



A. Last food given 5 hrs. 45 mins. before death. 



6 hrs. 30 mins. before death a subcutaneous injection of ^ of a grain 

 was given, hr. after another $ grain, and after another ^ hour 

 grain. Afterwards successiye doses of ^ grain of atropine were 

 given with the food up to nearly ^ grain (0'03 gram) ; the animal being 

 thus saturated with atropine both before and during the last meal. 



B. Liver considerably altered by psorospermic lesions, but about 

 normal in size. 



Cells large. 



Outlines of cells and the mitoma very indistinct. 



Meshes of the mitoma generally small, but a few large ones were 

 faintly indicated. 



Bile canaliculi generally indistinct ; where distinct they were very 

 narrow. 



Glycogen reaction well marked, but less so at the periphery of the 

 lobule than it should have been. 



Iron reaction did not show anything special. 



C. These changes are taken as the type of a liver in which the 

 secretory activity is diminished. 



I. Action of Atropine on a Fed Liver. 



A. Last food given 7 hrs. before death. 



Subcutaneous injection of T V of a grain (gram O002) of sulphate 

 of atropine was given 3 hrs. 30 mins. before death. 



. B. There were only a few psorospermic lesions in the organ. 

 Cells large. 



Outlines of the cells and the mitoma not very distinct. 

 Meshes of the mitoma small. 

 Bile canaliculi, where distinct, were narrow. 



C. These appearances were those of a fasting liver, with the ex- 

 VOL. LV. 2 H 



