436 Dr. L. Brunton and Mr. S. Del^pine. Changes [Apr. 2( 



ception of the size of the cells, and are taken to correspond to 

 diminished secretory activity. 



Action of Ammonia on a Fasting Liver. 



A. Last food given 25 hrs. before death. 



1 clc. of liquor ammonite, dilated with 9 c.c. of water, was injected 

 into the rectum 12 mins. before death (death accidental, possibly ac- 

 celerated by, but not, certainly, due to the drug)/ 



B. Liver very slightly diseased (psorospermosis) and of small size. 



Cells small. 



Mitoma more indistinct than normal, and the cellular cleavage 

 also. 



Meshes of the mitoma smaller than normal. 



Bile canaliculi seldom distinct. 



Glycogen reaction normal, i.e., there were no distinct glycogenic 

 granules. 



Sugar reaction, obtained after maceration in water for 24 hrs., was 

 a little more marked than under normal circumstances. 



Iron reaction considerably increased, but diffuse. 



C. Ammonia seemed in this case to have an action somewhat 

 similar to that of atropine, but to cause a greater splitting of organic 

 combinations of iron. 



Action of Ammonia on a Fed Liver. 



Last food given 8 hrs. and 30 mins. before death. 

 1 c.c. of liquor ammonite, diluted with 10 c.c. of water, was ad- 

 ministered per rectum 65 mins. before death. 



B. Liver cells rather large. 



Outline of the cells and the cytomitoma indistinct, instead of being 

 very distinct, as they should have been. 



Meshes of the mitoma small instead of large. 



Bile canaliculi generally indistinct. 



Glycogen reaction well marked in the hepatic zone only, instead of 

 being more general. 



Sugar produced in 24 hrs. after death was normal. 



Iron reaction more marked than normal, but was diffuse ; the 

 granules were, on the contrary, rather less than normal. 



I 



C. Generally speaking, the results were the same as in the fasting 

 state, and, with the exception of the changes in the iron reaction, 

 were similar to those produced by atropine. 





