1894.] produced on Liver Cells by various Compounds. 437 



Provisional Conclusions. 



The effect which the administration of various drugs has on tho 

 distinctness of the cellular rnitoma and on the distribution or arrange 

 ment of that mitoma and of the paramitoma, resembles, in the case 

 of a certain number of drugs, that of pilocarpine, and in others that 

 of atropine. The first drugs may be said to stimulate glandular 

 activity, the latter to restrain it ; only a few of those experimented 

 with seemed to have neither a stimulating nor a depressing action. 



On this basis we may subdivide the compounds studied into three 

 groups. 



1. Stimulating or excito- secretory group, with pilocarpine for a type. 



2. Neutral group. 



3. Depressing or depresso-secretory group, with atropine for type. 



1. Excito-secretory group. 



Of the following compounds, those heading the following list pro- 

 duced the most marked changes in the mitoma of the cells : 



Toluene, benzol, sodium iodide, pilocarpine, chrysophanic acid, 

 ammonium chloride, toluylene diamine, nitric acid. 



(Aniline seemed in one case to have a stimulating effect, but this 

 was doubtful.) 



2. Neutral group. 



No drug was altogether neutral, but two drugs seemed to have 

 little depressing, and still less exciting, action, though they evidently 

 produced degenerative changes in the cells ; in the doses used, they 

 acted probably too powerfully as poisons. These compounds 

 were aniline and phenol. 



3. Depresso-secretory group. 



The following compounds belong to this group : 



Phenol, atropine, ammonia. 



In each of the two great groups it is possible to recognise marked 

 differences based on the influence which the drugs had (1) on the 

 storage of glycogen ; (2) on the accumulation of compounds giving 

 the reaction of inorganic ferric salts in the liver. 



1. In the excito-secretory group. 



* Glycogenic Function. 



A. The following drugs caused marked increase of glycogen in the 

 liver : 



Sodium iodide, toluylene, diamine, chrysophanic acid (toluene ?) 

 (ammonium chloride ?) 



B. The following gave rise to no marked increase of glycogen, and 

 sometimes even to a diminution : 



(Ammonium chloride ?), nitric acid, pilocarpine, benzol. 



2 IT 2 



