438 Action on JAVCT Cell* l>n curious Compounds. [Apr. 26, 



** Ferrogenic Function. 



A. The following drugs caused a very marked diminution in the 

 amount of free iron in the liver : 



Sodium iodide, toluene, toluylene diamine. 



B. The following caused* a diminution in the quantity of iron, but 

 not to the same extent as the first, and the iron was often so dis- 

 tributed as to remind one of the appearances observed in an active 

 liver: 



Chloride of ammonium, nitric acid, pilocarpine, benzol (in the fed 

 liver). 



C. In one case only a doubtful increase of iron was found : 

 Benzol (in the fasting liver). 



2. In the group of depresso-secretory compounds. 



A. Ammonia caused a diminution of the glycogen and an increase 

 of iron. 



By its influences on the accumulation of glycogen and of iron, 

 phenol acts distinctly in the same way as the depresso-secretory com- 

 pounds ; thus it caused diminution in the glycogen and an increase 

 in the iron. 



Aniline caused little change in the glycogen, but a great accumula- 

 tion of iron in one case. The action of aniline evidently requires to 

 be studied more specially. 



B. Atropine caused a slight diminution in the glycogen and little 

 change in the iron. 



General Concluding Remarks. 



We are satisfied that much is to be learned of the affinities of drugs and 

 of their physiological action by the methods which we have been using 

 in this study. The anticipation of unknown difficulties in a field 

 practically new has caused us to spend much time in observations 

 which have not all proved of much use. We know now how to obtain 

 those results which are most useful. We are repeating some of the 

 experiments in order to test the value of our first results, and we are 

 slowly repeating the measurements which have already taken snch a 

 considerable amount of time. It would be unwise in the present 

 state of the inquiry to attempt to give more dogmatic conclusions than 

 those we offer provisionally. 



