Intestine, &c., on General Metabolism in Days. 79 



and l - 264 gram. In consequence of the increase of the .nitrogen in the 

 faeces, the apparent absorption of nitrogen per diem fell from 92*7 1 

 per cent, to 91'45 per cent, and 90'26 per cent., while, on the other 

 hand, in spite of the increased quantity of fat in the faeces, the absorp- 

 tion of fat rose from 93'91 per cent, to 96 '97 per cent, and 97 '96 per 

 cent, by increasing the fat in the diet. 



In dog 2 during the three periods examined, the first two were on 

 the same quantity of fat, and the results found correspond with those 

 found in dog 1. 



The next observation (Table V) was made on a dog in which a little 

 more than one-half of the large intestine was removed. It is seen that 

 on increasing the fat from 11'73 to 36'73 grams the quantity of urine 

 fell from 172 c.c. to 169 c.c., the specific gravity falling from 1035 to 

 1031. The nitrogen also fell from 5 '5 9 6 grams to 4 '9 91 grams. On 

 still further increasing the fat to 51*73 grams, the average quantity of 

 urine fell to 112 c.c. with a specific gravity of 1048, the quantity of 

 nitrogen being 4'680 grams when four days were analysed. As far as 

 the quantity of fasces is concerned, during two of the periods the dog 

 did not pass its faeces daily, so that the average can only be made 

 approximately. 



The increase in the quantity of fat is seen in this case to cause no 

 increase in the quantity of faeces, although the total quantity of faeces 

 are more than the previous normal dogs would lead one to suppose 

 ought to occur on that diet. The total nitrogen in the faeces also is 

 increased in quantity, although no increase occurs with the addition of 

 the fat. The fat analysis in the three periods remained practically the 

 same ; in consequence of this, the absorption is not altered by in- 

 creasing the fat. The total absorption of proteid varies from 86'91 

 per cent, to 89*85 per cent., that is to say less than the normal dogs, 

 while the fat absorption rose from 86 per cent, to 97 per cent., prac- 

 tically the same as is found when the large intestine is intact. 



In the next two dogs the entire large intestine was removed, and the 

 result obtained is seen in Table VIII. 



In dog 4, four periods were analysed, each having four days dura- 

 tion. During periods a and b the quantity of fat was 9 '71 grams, 

 while in periods c and d the quantity was 29*71 grams. 



It is seen that the quantity of urine during the periods a and b 

 varied very considerably, and the same occurred with the increased 

 quantity of fat. The cause of this variance it would be impossible to 

 explain; the tendency, however, is for the quantity to slightly 

 decrease with the increased quantity of fat, and specific gravity to do 

 the same. 



At the same time the decrease in quantity on increasing the fat is 

 not nearly so marked as in the normal dogs. The increase of fat in 

 the diet, however, brings out the same proteid sparing action as the 



G 



