Relation of the Toxin and Anti-Toxin of Snake- Venom. 89 



injecting, failed to counteract the venom. Even as much as 9 c.c. and 

 15 c.c. was equally useless, although the animals in the experiments in 

 which 8 c.c. and 10 c.c. were employed lived. 



Series A. 



The further experiments detailed in the present paper afford a 

 reasonable interpretation of the very different efficacy of anti-toxic 

 serum under these two conditions. They are also an additional con- 

 firmation of the conclusions regarding the direct chemical nature of 

 the antagonism between the toxins and anti-toxins of diphtheria and 

 snake-poison respectively, which were drawn by Cherry and myself in 

 a recent paper.* Moreover, some inferences which seem to me to be 

 necessitated by the experimental results are of practical importance 

 in the treatment of snake-poisoning, and not devoid of interest in their 

 bearing upon the relations of toxins and anti-toxins in general. 



The experiments arranged in tabular form below were made with 

 the object of obtaining definite data concerning the proportions of anti- 

 toxin to toxin necessary to save an animal under the following three 

 conditions : 



'Eov. Soc. Proc.,' vol. 63, p. 420, 1893. 



