106 Messrs. Kanthack, Durham, and Blandfofd. 



In days there is also fever, the temperature becoming subnormal on 

 approach of death. 



In rabbits pyrexia is common, and generally the temperature is 

 elevated throughout the disease, but it may fall suddenly to normal. 

 The temperature curve is always irregular, and no relation between 

 the temperature curve and the hsematozoal curve could be established. 



In cats also the fever is well marked, the temperature falling quickly 

 towards the end. 



It is difficult to speak with certainty of the temperature in such 

 small animals as rats and mice. 



In guinea-pigs, representing less susceptible animals, fever as a rule is 

 riot a special feature. The temperature is as irregular as it is in the 

 normal animal, but the animal shows paroxysmal rises from time to 

 time, sometimes above 41; these may be accompanied by an acces- 

 sion of haematozoa into the circulation, but this is not a constant 

 feature. 



3. (Edema is common in certain animals, such as the horse, rabbit, 

 cat, and dog, and is most marked about the head, legs, belly, or 

 genitals. In smaller animals, such as rats and mice, it is not usual, and in 

 guinea-pigs it has not been observed. In dense tissues, as the rabbit's 

 ear, there may be a local oedema at the site of inoculation. 



Rabbits exhibit a special tendency to oedema of the external genital 

 organs. There is often great and progressive swelling of the prepuce 

 or labia, as the case may be. The swollen parts often excoriate and 

 become sore and covered by crusts, so that the animal is in a sorry con- 

 dition. 



4. Changes in the Eyes and Nose. In cats, dogs, rats and rabbits 

 turbidity of the aqueous humour, fibrinous plaques in the anterior 

 chamber, arid corneal opacities are occasionally observed. In rabbits a 

 muco-purulent conjunctivitis is common, and this may be followed by 

 an opacity of the cornea and a turbidity of the aqueous humour, 

 which under such conditions shows hsematozoa microscopically as well 

 as leucocytes. Hsematozoa have also been discovered in the con- 

 junctival discharge in the earlier stages of the disease. Vascular 

 corneal ulcers sometimes occur in dogs, and the conjunctivitis of cats, 

 dogs, rats and rabbits is frequently associated with oedema of the 

 eyelids and face. In rabbits the eyelids and nose frequently become 

 almost entirely closed up by the drying of the secretion ; in the latter 

 case they breathe with great difficulty, keeping their mouths open. 

 This condition has been described by Rouget (op. cit.). 



5. Anaemia. Some degree of anaemia is always present, but it does 

 not seem to be so extreme as to be the sole attributable cause of death, 

 arid points rather to a disturbance in the haematopoietic or the haema- 

 tolytic mechanisms. 



The number of red blood corpuscles steadily diminishes and nu- 



