108 Messrs. Kanthack, Durham, and Blandford. 



to the seat of inoculation heing always largest. This observation is 

 important, because from the relative size of the glands it is possible to 

 determine the seat of infection. To this allusion has already been 

 made, when the effects of feeding were discussed. The glands are 

 generally red, congested, juicy, and oedematous ; in a few instances 

 haemorrhagic extravasation has been observed. In some cases all 

 lymphatic glands in the body are enlarged, in others a particular 

 series only. If a rat be inoculated in the right thigh, the glands in the 

 left axilla and left groin suffer last. 



(2) The spleen is much enlarged, with but few exceptions, and it is 

 generally firm, friable, and dark coloured. 



(3) The liver generally shows some enlargement and may be fatty. 



(4) Wasting of the muscles and atrophy of the fat is, as a rule, not 

 well marked. 



(5) Sub-pleural ecchymoses are sometimes present in the lungs, 

 accompanied by a small amount of pleural fluid. 



In rabbits the general enlargement of lymphatic glands is less notice- 

 able. The spleen is generally enlarged. Petechial ecchymoses are 

 rare. Fatty degeneration of the liver is always present, and muscular 

 wasting is often extreme. Enlargement of testes has been observed. 



In dog* muscular wasting is well marked, the animal being often 

 reduced to a skeleton, but the fatty tissues are generally not much 

 affected, except at the base of the heart, where the fat may undergo 

 oedematous degeneration. The general enlargement of the lymphatic 

 gland is well marked, and, as in the rat, the glands are oedematous and 

 congested, yellowish, or even show haemorrhagic extravasations. 



The spleen is also greatly enlarged, granular, firm and friable. 



Pericardial effusion is common, pleural effusion may be present. 



Sub-pericardial petechiae and haemorrhages occur frequently, sub- 

 peritoneal occasionally, and sometimes also sub-mucous in the intestines 

 and stomach. 



In cah wasting is pronounced, the glands are greatly enlarged, the 

 spleen is also enlarged, the liver is slightly enlarged. Haemorrhages 

 beneath the pleura and pericardium have been noticed. 



In guinea-pigs, which clinically often show no changes or symptoms 

 at all, the morbid changes after death are not very well marked. The 

 spleen is generally moderately enlarged, and occasionally even con- 

 siderably ; it is often very soft and rather pale. The lymphatic glands 

 are distinctly, but as a rule only slightly, enlarged, those corresponding 

 to the seat of inoculation being always the most affected. 



Haemorrhages have been observed in the lungs and in the stomach ; 

 serous effusions and oedema have not been noted. 



In all these animals the bone-marrow is sometimes dark red in colour, 

 at other times natural, or paler than it should be. In the shafts of the 

 long bones the fat disappears and becomes replaced by " red " marrow. 



