Observations on the Effects of partial Thyroidectomy. 125 



The other six dogs did not die, but four of them had temporary 

 symptoms ; they were submitted to further thyroid excisions, from 

 which they all died, one after simultaneous excision of both thyroid 

 lobes, three after removal of one thyroid lobe only ; two survived this 

 operation, one of them having temporary symptoms ; these both died 

 after removal of the remaining lobe. 



In this series, too, besides the usual symptoms of tremors, unstable 

 gait and paralysis, emaciation and weakness, eye symptoms were 

 observed, in four out of the seven dogs. 



In two, after the partial parectomy, the eyes became unduly promi- 

 nent, but subsequently, after a further operation on the thyroid, the 

 palpebral fissures became narrow, and the eyeballs retracted. 



In one of the partial parectomies no change was noticed, but after 

 one of the thyroid lobes had been excised the eyes became unduly 

 prominent, and after the remaining lobe had been excised the palpebral 

 fissures became narrowed, the eyeballs retracted, and the animal died. 



In one, after removal of some of the parathyroids, and also, after an 

 interval, of one of the thyroid lobes, no change was noticed ; but after 

 the removal of the remaining lobe with a parathyroid attached, the 

 palpebral fissures became narrowed, and the eyes retracted. 



Altogther in the eighteen dogs operated on, ocular changes were 

 noticed in six. 



In the partial parectomies, changes in the thyroid lobes left were 

 also observed, the same as those found in complete parectomies and in 

 Graves's disease. 



Similar effects on the eyes were also noticed in monkeys, but these, 

 eight of them, were subjected to total excision of the thyroid including 

 the parathyroids ; four of the monkeys died as a consequence of the 

 operation : one in thirteen days, one in thirty-six days, one in sixty- 

 eight days, and one in 262 days ; three of them were treated with 

 thyroid extract, but this, although it produced marked benefit, did not 

 save their lives. One monkey was killed by accident ; the other three 

 are still alive. 



As to their eye symptoms : in two the eyes appeared to be more 

 prominent, and the palpebral fissures were wider; and in two the 

 palpebral fissures were narrowed, and the eyes appeared sunken. In 

 four no change could be seen. Drawings of the monkeys were made, 

 before and after operation. 



