304 Prof. V. Harley. Influence of Removal of Large Intestine and 



Summary. 



The conclusions to be drawn from the above experiments can be 

 briefly summarised, so that the general results will be more readily seen. 



1. The large intestine itself excretes a substance which contains 

 proteids, fat, and salts, thus resembling " Hermann's loop," but at the 

 same time contains no colouring matter, and so differs from the con- 

 tents of the small intestine. 



2. Increasing the quantity of fat on a standard diet in normal 

 animals leads to a decrease in the quantity of urine passed, together 

 with a decrease in the amount of nitrogen eliminated in the urine, but 

 tends to increase its specific gravity. The quantity of faeces is 

 increased when the quantity of fat in the diet is increased, and this is 

 accompanied with an increase in the nitrogen eliminated, and a more 

 marked increase in the quantity of fat eliminated from the bowel. 



In consequence of the increase in the nitrogen in the faeces, there is 

 a decrease in the amount of nitrogen absorbed from the alimentary 

 canal, but in spite of the increase in the quantity of fat in the fasces, 

 the increased quantity in the diet leads to an increase in the amount 

 absorbed. The animal's weight increases, and this is due in part to 

 the increase of fat tissue by the additional fat in the diet, but mostly 

 to the fresh fat acting as a sparer of proteid destruction in the organ- 

 ism. (Table III.) 



3. That increasing the quantity of fat in a standard diet in an 

 animal after partial removal of the large intestine yields similar 

 results as regards the urine and general metabolism to those found in 

 normal dogs, except that the increased quantity of fat in the diet does 

 not appear to cause an increase in the amount of the fasces, or an 

 increase in the nitrogen of the faeces, and only a slight increase of 

 fat in the faeces. 



The partial removal of the large intestine causes a diminution in the 

 absorption of nitrogen from the alimentary canal, which is only slightly 

 influenced by increasing the fat in the diet. The absorption of fat 

 seems to be influenced in the same manner as in normal dogs by increas- 

 ing the fat in the diet. (Table V.) 



4. The increased quantity of fat in a standard diet in dogs, after 

 total removal of the large intestine, causes a decrease in the quantity 

 of urine, and nitrogen in the urine, with a tendency to an increase in 

 specific gravity. 



The quantity of faeces is increased by increasing the fat in the diet, 

 but the quantity of nitrogen and fat in the faeces is uninfluenced by 

 the larger amount of fat taken, so that these dogs do not correspond 

 to what is found in normal dogs. (Table VIII.) 



5. The influence of increasing quantities of fat in the diet on the 

 quantity of water in the fasces. 



