1904.] Production of a, Specific Gastrotoxie Serum. 145 



pig's cells should anchor the immune body, whilst the rabbit's cells 

 will not. On the other hand, if we accept the view that there is one 

 immune body only, but that it has two cytophilic affinities, that corre- 

 sponding to the rabbit's receptor being saturated by an anti-immune 

 body, but that corresponding to the guinea-pig's receptor being free, 

 the above difficulty vanishes. 



(4.) EFFECTS OF INJECTION OF THE STOMACH CELLS OF THE 

 GUINEA-PIG INTO THE GUINEA-PIG. 



The serum in this case was shown to be toxic by injecting it into a 

 rabbit, when typical necrosis resulted. A difficulty encountered here 

 is due to the fact that a sufficient amount of blood cannot be obtained 

 from the guinea-pig in order to inject an amount corresponding to the 

 weight of the rabbit which would lead to a result as marked as that 

 obtained in the guinea-pig's stomachs described above. 



This experiment also shows that when an animal absorbs cells which 

 have been taken from the body of an identical animal its blood becomes 

 toxic. 



(5.) ACTION OF NORMAL RABBIT'S SERUM ON THE GUINEA-PTG. 



The blood serum of the rabbit is to some extent haemolytic for the 

 guinea-pig's red corpuscles. On injection of the serum into a 

 guinea-pig, even in large does (20 c.c.), no lesions are found in the 

 stomach or alimentary canal such as result from haemolysis. In one 

 case a patch of engorged vessels was seen in the stomach, but no 

 hemorrhage or necrosis was to be observed. 



(6.) ACTION OF STRONGLY H^MOLYTIC SERUM. 



After a rabbit has received several injections of guinea-pig's red 

 corpuscles a marked effect is observed on injecting the rabbit's blood 

 serum into a guinea-pig. The lesions produced consist of haemorrhage 

 with distortion and solution of the blood corpuscles. The haemor- 

 rhages are best seen in the alimentary canal. They occur in the 

 stomach and lead to erosions of the mucous membrane as a secondary 

 consequence, but patches of necrosis in the mucous membrane are not 

 seen. Haemorrhages are also seen in the lymphatic follicles of the 

 intestine, especially the colon. There is intense engorgement of the 

 organs and haemorrhages may occur all over the mesentery. 



Effects of Heat. On heating the haemolytic serum to 50 60 C. for 

 an hour, its action is not destroyed, the guinea-pig's serum being able 

 to complement the haemolytic amboceptor. The differences between 

 the action of a haemolytic and a gastrotoxic serum are thus seen to 

 be very considerable. 



