1904.] Staphylococcus pyogenes ~by Human Blood, etc. 



155 



On the date when he presented himself for treatment he had two 

 boils on his neck. It will be seen that the phagocytic ratio recorded 

 for that day was 0*6 the phagocytic power of the normal control blood 

 being throughout taken as unity. 



On the next day and the day subsequent phagocytic ratios of 0'7 

 and 1*1 respectively were recorded. This altogether spontaneous 

 improvement of the phagocytic power went hand in hand with a striking 

 improvement in the condition of the boils. 



CURVE 1. 



67 8 9 10 ii 



:='C 



12 13 14 15 16 17 18 



13 20 21 22 23 2* 25 



The patient was now inoculated with a quantum of sterilised culture 

 of Staphylococcus corresponding to 2,000,000,000 of staphylococci. 

 The culture employed was derived from the patient's boils. 



On the day subsequent to inoculation the patient's phagocytic power 

 was found to be reduced. Contemporaneously with the development 

 of this " negative phase," an irritable pimple developed on the neck. 

 We may see in this, for it is a phenomenon which has manifested itself 

 again and again in this connection with our inoculations, an indication 

 that the negative phase is associated with a diminished resisting power 

 to invasion by the Staphylococcus. 



On the second day after the inoculation an improvement in the 

 phagocytic power was recorded. The " positive phase," which is 

 here heralded, reached its acme on the eighth day subsequent to 

 inoculation. 



On the twelfth day the patient was re-inoculated with the same 

 quantum of vaccine as was employed on the first occasion. As on 

 the previous occasion, inoculation was followed by a negative, 

 succeeded by a positive phase. For a period of weeks after the 



