GENERAL PROPERTIES: THE CORPUSCLES. 421 



layer of supernatant plasma. Among themselves, also , the corpuscles 

 differ slightly in specific gravity, the red corpuscles being heaviest. 



Red Corpuscles. The red corpuscles in man and in all the 

 mammalia, with the exception of the camel and other members of 

 the group Camelidae, are biconcave circular discs or, according to 

 some authors, bell-shaped corpuscles without nuclei; in the Cam- 

 elidae they have an elliptical form. Their average diameter in 

 man is given as 7.7 // (1 p. == 0.001 mm.); their number, which 

 is usually reckoned as so many in a cubic millimeter, varies greatly 

 under different conditions 6f health and disease. The average 

 number is given as 5,000,000 per c.mm. for males and 4,500,000 for 

 females. The red color of the corpuscles is due to the presence in 

 them of a pigment known as "hemoglobin." Owing to the minute 

 size of the corpuscles, their color when seen singly under the micro- 

 scope is a faint yellowish red, but when seen in mass they exhibit 

 the well-known blood-red color, which varies from scarlet in arterial 

 blood to purplish red in venous blood, this variation in color being 

 dependent upon the amount of oxygen contained in the blood in 

 combination with the hemoglobin. Speaking generally, the func- 

 tion of the red corpuscles is to carry oxygen from the lungs to the 

 tissues. This function is entirely dependent upon the presence of 

 hemoglobin, which has the power of combining easily with oxygen 

 gas. The physiology of the red corpuscles, therefore, is largely con- 

 tained in a description of the properties of hemoglobin. 



Condition of the Hemoglobin in the Corpuscle. The finer structure 

 of the red corpuscle is not completely known. It is usually stated 

 that the corpuscle is composed of two substances, stroma and hem- 

 oglobin, together with a certain amount of water and salts and 

 also a certain amount of lecithin and cholesterin. The stroma is a 

 delicate, extensible, colorless substance that gives shape to the 

 corpuscles; it forms a meshwork or spongy mass in which the 

 hemoglobin is deposited. This latter substance forms the chief 

 constituent of the corpuscle, since it makes about 32 per cent, of the 

 weight of the normal corpuscle, and when dry from 90 to 95 per 

 eent. of the total solid material. According to another view the 

 corpuscles are vesicles with an external envelope or pellicle in 

 which lecithin and cholesterin are found, while the hemoglobin is 

 contained within.* Whichever view may be correct, great interest 

 attaches to the presence of the lecithin and cholesterin, whether 

 these substances are found in an external membrane or in a stroma 

 permeating the corpuscle. According to Pascucci the lecithin and 

 cholesterin constitute as much as 30 per cent, of the dry weight of 



* For recent discussions upon the histological structure of the corpuscles 

 see Weidenreich, "Anatom. Anzeiger," 1905, xxvii., and Schilling-Toreau. 

 "Folia Haematologica," Pt I, 1912. 14. 95. 



