70 SPECIAL VETERINARY THERAPY 



On these lines, our selection fell on thiosinamine, 

 whose action on sclerotic processes is selective. It 

 can be obtained in sterile, graduated ampules, under 

 the trade name of "Fibrolysin," and it is in this form 

 that we use it. In our early work along this line, we 

 deemed it essential that the drug be deposited sub- 

 durally. Later we found that the same results could 

 be obtained by epi-dural injections. 



The modus operanjdi is as follows, under chloro- 

 form : 



An area of an inch square over the alto-axoid space 

 is shaved and thoroughly cleaned. With a very fine 

 hypodermic needle a puncture is made straight down 

 onto the cord, passing the needle slowly in until a 

 sudden freedom from resistance gives evidence that 

 the point has entered the neural canal. This is easy 

 to recognize after a very little practice. The head is 

 to be sharply flexed on the sternum while the entrance 

 is made and until the needle is withdrawn. 



When the characteristic sensation of absence of 

 resistance is felt, the hypodermic syringe, containing 

 the fibrolysin at body temperature, is attached to the 

 needle and the contents very slowly injected. The 

 needle is withdrawn quickly and the seat of puncture 

 is then painted with tincture of iodine. This com- 

 pletes the treatment. The dose is one cubic centi- 

 meter of fibrolysin to twenty-five pounds of live 

 weight. 



Within a few hours after the injection, the animal 

 exhibits typical symptoms of brain trauma, delirium 

 and partial coma. This passes off in from eight to 



