CANCER OF THE KIDNEY. 389 



Next morning the patient appeared very feeble, and moved with 

 difficulty. The conjunctiva was dull and infiltrated ; the pulse 85 ; the 

 respiration slightly accelerated, short, and sighing. Nothing abnormal 

 was discovered on auscultating the lungs and heart. Manipulation of 

 the abdomen was painful, especially towards the spine. Rectal ex- 

 ploration discovered nothing abnormal in the pelvic organs. Urine 

 passed during the night was slightly reddish, and contained about 

 forty-five grains of albumen per quart. On microscopical examination 

 cylindrical casts, leucocytes, a few red blood-corpuscles, and some epi- 

 thelial cells were discovered in it. 



Diagnosis. — Acute nephritis. 



Treatment. — Milk diet and bicarbonate of soda, emollient enemata. 



The animal's condition became rapidly aggravated. On the 24th 

 December the patient was seen to be lame on the right hind leg. 

 Nothing could be detected on examining the limb. 



On the 27th the scrotum became swollen, hot, and painful. When 

 punctured reddish pus escaped. Pulse 120, respirations 28, tempera- 

 ture 39° C. 



On the 29th weakness was extreme. Pulse 130, respirations 28, 

 temperature 40° C, The animal several times took milk, but almost 

 immediately afterwards vomited. The urine was very red in colour. 

 A little discharge escaped from the nostrils. In the evening the pulse 

 was 160, respirations 25, temperature ^y^ C. Died during the night. 



Post-uwrteui Examination. — The kidneys were large and black in 

 colour. Sections were deep red, marbled with a few whitish points, 

 indicating little abscesses distributed through the cortical and medullary 

 substances. The pelvis of the kidney contained a little purulent urine. 

 The liver, spleen, and lungs were large and congested. 



On microscopic examination the tissue of the kidneys appeared 

 greatly changed throughout. The glomeruli and walls of the tubuli 

 were inflamed. The glomeruli were filled with a granular material, 

 exuded between the capillaries and Bowman's capsule. The tubes 

 were obstructed by cylinders, and their epithelium was granular. The 

 pericapsular and intertubular connective tissue was infiltrated with 

 migratory cells. Sections coloured by Gram's and Weigert's methods 

 showed streptococci in short chains in the capillary vessels, in the 

 exudate, in the glomeruli, and in the tubes. Others, surrounded by 

 masses of leucocytes, were present at certain points in the interstitial 

 tissue. 



CANCER OF THE KIDNEY. 



100. An eight-year-old spaniel, left in hospital 19th March, 1892. 



For the preceding month it had appeared very thin, although its 

 appetite had remained good until a few days previous to entry, when it 

 refused food, and remained continually lying down in a moist corner 

 of the courtyard, in which it was left. 



State on Examination. — The animal was very feeble. The muscular 

 tissues, and especially the temporal muscles, were excessively wasted. 

 The breath was offensive. A large, moderately firm, subcutaneous 



