5l8 CLINICAL VETERINARY MEDICINE AND SURGERY. 



raised by a multitude of small greyish nodules varying in size from a 

 pea to a hazel-nut. 



On section these nodules were found throughout the lung sepa- 

 rated by a very small but variable amount of lung tissue. Their 

 consistence was that of a hepatised area in the horse ; the invaded 

 parts were airless and contained no softened centres. The bronchial 

 glands were enlarged and firmer than normal ; some contained black 

 pigmented centres (carbon). 



205. A setter bitch with tumour about the size of a man's fist, which 

 was excised. The patient remained dull after operation, but no definite 

 symptoms appeared until the tenth day, when the temperature rose to 

 105° F., and the respirations became slightly hurried. The temperature 

 gradually rose to 106° F., the symptoms of dyspnoea became more 

 intense, and on the fourteenth day the patient died. The microscopic 

 appearance of the lungs of this animal was practically the same as in 

 Case 204. The nodules, however, were hardly so numerous, nor were 

 they as firm ; their consistence was that of a normal testicle. 



The microscopical appearance was the same in both cases, and sug- 

 gestive of what ma}' follow from an infecting agent being arrested in 

 the pulmonary capillaries. At various points the spongy tissue was 

 obliterated by very dense collections of oval-shaped cells resembling 

 certain forms of glandular epithelium, but only in a few cases was there 

 an acinal arrangement. Each cellular area was surrounded by a 

 limiting membrane, which was not of the same thickness in every case. 

 In some cases this membrane was the alveolar wall, in others the inter- 

 lobular septum ; in the latter case the interfibrous spaces were invaded 

 and the fibrous tissue cells were proliferating. The majority of the 

 cells had a diameter of 5 ^ ; a few were somewhat larger. The seg- 

 mentation of their nuclei indicated the activity with which they were 

 dividing. In the more open parts the alveolar walls were thickened, 

 and their cavities contained a few catarrhal cells. The new formations 

 in the bronchial glands were identical in structure with those in the 

 lungs. 



Note. — Adenomata are the commonest malignant neoplasms in the 

 bitch, and their primary seat is usually in the mammary gland. The 

 two cases just described show in how astonishingly short a time the 

 secondary (metastatic) growths may develop ; they give an idea of 

 when symptoms of secondary formation may be expected after operation, 

 or in other words at what date after operation a favourable prognosis 

 may be ventured on. In both cases symptoms of dyspnoea only 

 occurred a few days before death, in Case 205 on the tenth day 

 after that on which we might assume the infecting agent gained the 

 venous stream. During this time the new cells were actively dividing 

 and obliterating the lung tissue, which on the fourteenth day was so far 

 destroyed as to render life impossible. As the primary lesion was in 

 the mammary gland, and the secondary growths in the lungs and 

 bronchial glands, it is probable that the infecting agent travels both by 

 the venous and lymph streams. 



Prof. Stockman's cases, Journ. Coinp. Path, and Therap., 1895, p. 254. 



