534 CLINICAL VETERINARY MEDICINE AND SURGERY. 



lated in the abdominal cavity with a few drops of an emulsion prepared 

 from the liver of tuberculous fowls : three of them died between sixty- 

 nine and eighty-seven days after inoculation ; another was killed at the 

 end of io8 days. In these four Simma.ls post-inortein examination showed 

 generalised tuberculosis ; the peritoneum, and especially the epiploon, 

 were dotted over with little tuberculous granulations ; the liver and 

 spleen were crammed with them ; the lungs and kidneys, however, con- 

 tained a smaller number. Several times we microscopically examined 

 the invaded organs, which we found contained large numbers of bacilli ; 

 the structure of the tubercles showed nothing special. 



We must now mention an experiment in which the development of 

 avian tuberculosis showed peculiar features. 



On the i6th June, 1890, two rabbits were inoculated from the liver 

 of a fowl. One died in sixty-nine days from generalised tuberculosis. 

 The other remained in good health until the 3rd January, iSgi, at 

 which time swelling of the right hock was noted ; some days later the 

 radio-carpal joint of the same side was in turn attacked. On palpation 

 numbers of fungous growths could be detected developed around the 

 joints first invaded ; these soon projected beneath the skin ; at the 

 antero-external part of the carpal region they perforated the skin, and 

 appeared externally as reddish, soft granulations. In order to make 

 certain as to the nature of the articular lesions, we had, before the 

 external appearance of the granulations, punctured the parts aseptically 

 with a Pravaz's syringe, and thus obtained a few drops of liquid con- 

 taining the characteristic bacilli. 



In spite of the existence of these fungating growths the animal's 

 general health remained excellent, and its condition even improved. 

 On the 5th January the subject weighed 5 lbs. g^ oz. At that time 

 we subcutaneously injected "25 c.c. (that is at the rate of o'l c.c. per 

 kilo, of body-weight) of tuberculin. We had previously satisfied our- 

 selves that a similar or even larger dose produced no disturbance in a 

 normal rabbit. The injection was made at 11 a.m., and the animal 

 seemed to experience no effect throughout the day. At 7 a.m. next 

 morning, however, it was dead. 



On post-mortem examination the lungs were found engorged with 

 blood ; they contained a few disseminated tuberculous granules. The 

 liver was congested, and contained five or six tubercles ; two were also 

 found in the spleen, which was of very large size. The kidneys were 

 enormous and violet in colour : they only contained two or three little 

 granules. Examination of the affected joints showed that the fun- 

 gating growths had invaded the synovial membranes and periarticular 

 tissues. 



