536 CLINICAL VETERINARY MEDICINE AND SURGERY. 



In the latter cases the results were as follows : — At the point of 

 inoculation a small caseous abscess containing numerous bacilli formed, 

 but healed in a few weeks. Whether or not this local lesion developed, 

 the lymphatic glands in the neighbourhood of the inoculated spot (in 

 this case the inguinal glands) generally became enlarged ; instead of 

 extending and becoming generalised, however, this glandular inflamma- 

 tion, which was especially marked from the eighth to the ninth or 

 twentieth day, retroceded, and ended by disappearing. Most frequently 

 the animals remained in good health, and did not fall away in condition. 

 They showed nothing indicating disease ; a local infection, characterised 

 by the inoculation abscess and by inflammation of lymph-glands, cer- 

 tainly occurred at the time, but these lesions were temporary, and 

 rapidly disappeared. 



Of twenty-four guinea-pigs inoculated six died spontaneously, 

 one rapidly in r6 days, as in Straus and Gamaleia's experiments ; the 

 others lived for a period varying between 30 and 164 days. The 

 post-mortem examination of these animals was negative, in the sense 

 that examination of the viscera showed no lesion resembling tuber- 

 culosis. We simply add that one guinea-pig showed at the point of 

 inoculation in the peritoneum a small, entirely encysted caseous abscess. 

 The other animals remained in perfect health, and were killed 

 between the iiith and 248th day after inoculation; in nine the results 

 were negative ; there was no appreciable lesion except in one guinea- 

 pig, which showed a little encysted abscess in the peritoneum. 



In short, of the fifteen guinea-pigs inoculated with avian tuber- 

 culosis which died spontaneously, or were killed, the organs remained 

 absolutely unaffected ; no appreciable lesion was found except in two 

 animals, each of which exhibited a caseous abscess similar to those 

 already discovered by Cornil and Megnin. 



Six other guinea-pigs were killed like the preceding whilst still in 

 very good bodily condition, but the autopsy showed the presence of 

 tuberculous granulations. The number and the localisation of these, 

 however, differed entirely from what has been noted after inoculation 

 with human tuberculosis ; instead of becoming generalised the lesions 

 were confined to one or two viscera, or to the peritoneum ; in one case 

 the serous membrane was alone affected, five or six miliary granula- 

 tions being found in the perihepatic portion. In addition, infection 

 had extended to the liver and spleen, but careful examination was 

 required to detect it. Each of these viscera contained three or four 

 small granulations, so that the appearance of the organs was hardly 

 modified. In particular the spleen showed none of the hypertrophy 

 generally seen in experimental tuberculosis in rodents. 



