AVIAN TUBERCULOSIS. — EXPERIMENTAL STUDY. 547 



prising five animals w^hich had been simultaneously inoculated in the 

 veins and peritoneum with an emulsion of guinea-pig's liver. The first 

 of these five fowls was killed at the end of eleven days ; its organs 

 were unaffected. The second, killed at the end of twenty-four days, 

 showed no visceral lesion, but the bacilli of human tuberculosis were 

 still present in its liver, for inoculation of a guinea-pig with fragments 

 of the organ produced typical tuberculosis. The third was killed on 

 the thirty-fifth day ; it was rather thin : on post-mortcni examination 

 sero-fibrinous ascites was noticed ; the liver was slightly enlarged, and 

 crammed with extremely small tuberculous granulations ; the spleen 

 was also slightly enlarged, but contained no granulations. The fourth, 

 killed on the thirty-eighth day, also showed numerous granulations in 

 the liver and on the mesentery. The fifth was killed at the end of 

 fifty-nine days ; in it the lesions were less marked ; somewhat 

 numerous but small tubercles, practically similar to those seen in 

 the fowl, directly inoculated with human tuberculosis, had developed 

 in the liver. 



With tuberculous material from the fowl killed at the end of thirty- 

 five days we inoculated another fowl, which remained in good health. 

 It was killed at the end of eighty-six days ; we found ascites and small 

 granulations in the liver and spleen. 



All these facts are given in the following tables : 



MAN. 



Pulmonary tuberculosis. 



August 24th, 1890. 



I 



Guinea-pig. 



Died September 21st (28 days afterwards). 



Ascites ; tuberculosis of the peritoneum, liver, and spleen. 



I I 



Guinea-pig. Fowl. 



Killed October iSth (28 days after- Killed March 20th, 1891 (180 days 



wards). afterwards). 



Tuberculosis of the peritoneum, liver. No lesion, 



and spleen. 



Fowl.* Fowl. Guinea-pig. • 

 (Reincculated March i8th.) (Reinoculated March Killed November 2nd, 

 Killed July 12th, 1891 (266 13th.) 1890 (15 days afterwards), 

 and 121 days afterwards). Killed July 12th, 1891 Tuberculosis of the peri- 

 No lesion. (266 and 121 days after- toneum, liver, and spleen. 



wards). I 



No lesion. \ 



I \ n I 



Guinea-pig. Fowl.'" Fowl.'^ Fowl. 



Died November 28th, Killed January 24th, Killed July 12th Killed July I2th (252 



1890 (26 days). 1891 (83 days). (252 days). days). 



A few tubercles in the No lesion. No lesion. No lesion, 



spleen. 



