548 



CI-INICAL VETERINARY MEDICINE AND SURGERY, 



GUINEA-PIG. 



Generalised tuberculosis. 

 Killed March 13th, 1891. 



Guinea-pig. 

 Killed May 6th 



(54 days). 



Generalised 

 tubercidosis. 



Fowl.* 



Killed March 



24th (11 days). 



No lesion. 



Guinea-pig. 

 Died May 25th (19 



days). 

 Generalised tuber- 

 culosis. 



Fowls. 



Fowl.* 



Killed April 



6th (24 days). 



No lesion. 



Guinea-pig. 

 Killed July 12th 



(97 days). 

 Tubercidosis of 



Fowl.* 



Killed April 



17th (35 days). 



Ascites; granu- 



lafions in the 



liver. 



1 

 Killed July 12th 



(86 days). 

 Ascites ; tuber - 



Fowl.* 

 Killed April 

 20th (38 days). 

 Granulations 

 on the perito- 

 neum and in 

 the liver. 



I 



Fowl.* 



Killed May nth 



(59 days). 

 Very small tu- 

 bercles in the 

 liver. 



the liver, spleen, culosis of the 

 and lungs. liver and spleen. 



I. Killed May 22nd (16 days). No lesion. 

 II. Killed May 30th (24 days). 



III. Killed June 7th (31 days). ,, 



IV. Killed June 15th (39 days). ,, 

 V. Killed June 22nd (46 days). ,, 



VI. Killed July ist (55 days). „ 



VII. Killed July 9th (63 days). 

 VIII. Killed July 17th (71 days). 



IX. Killed July 19th (73 days). „ 



X. Killed July 26th (80 days). 

 XI. Killed Sept. 14th (131 days). ,, 

 XII. _ — _ — 



Of the first five fowls inoculated in this last series, three showed 

 tuberculous lesions on post-mortem examination. When these results 

 were laid before the Societe de Biologic various objections were made, 

 the chief of which are as follows : — ( i) The best evidence of the immunity 

 of fowls against human tuberculosis is to be found in the fact that none 

 died spontaneously ; (2) we were wrong in not using cultures for our 

 inoculations ; (3) we had mistaken for tuberculosis, nodular lesions 

 produced by the injection of emulsified tuberculous material ; (4) we 

 should have experimented on fowls already affected with avian tuber- 

 culosis. 



To the first objection we reply, that if none of our fowls died spon- 

 taneously it was for the simple and decisive reason that we killed them. 



To the second, that of the various methods of inoculation with 

 human tuberculosis (direct inoculation, or inoculation with cultures 

 prepared in living animals, or on inert media), we consider that none 

 is superior to the others unless it give better results. 



To the third, that histological and bacteriological examination 

 clearly proved the tuberculous nature of the lesions noted. 



Finally, in order to refute the last objection, we shall not shelter 

 ourselves behind the assurance of the person who furnished us with the 



