AVIAN TUBERCULOSIS. EXPERIMENTAL STUDY. 55 I 



OX. 



Pleural and pulmonary tuberculosis. 

 November 15th, 1889. 



I 



Cat. 



Died November i6th (31 days). 



Generalised tuberculosis . 



I 



Fowl. 



Killed August 3rd, 1890 (230 days). 



No lesion. 



OX. 



Pleural and pulmonary tuberculosis. 

 March i8th, 1890. 



I 



Fowl. 



Killed October 12th (208 days). 



No lesion. 



Inoculation with Tuberculous Lesions from the Dog, Cat, and Horse. — 

 Finally, we come to the last series of experiments in which material for 

 inoculation was obtained from animals which rarely suffer from 

 tuberculosis. 



In the first the virus was obtained from a dog with tuberculosis of 

 the lung and pleura. From a pulmonary centre which contained large 

 numbers of bacilli we inoculated two guinea-pigs and two fowls. The 

 fowls resisted, while the guinea-pigs died with all the ordinary sym- 

 ptoms of tuberculosis. 



In the second the virulent material was obtained from a case of 

 pulmonary tuberculosis in the cat. The inoculation was successful in 

 the guinea-pig, but failed in the fowl. What renders this second series 

 interesting is that the virus appeared pathogenic for the horse, intra- 

 venous inoculation producing death in twenty-four days. On post- 

 morteni both lungs were found affected with miliary tuberculosis, the 

 separate points being extremely small and confluent ; this lesion was of 

 surprising intensity. The bacilli inoculated must have been very 

 virulent, for every one knows that the horse is not specially sensitive to 

 tuberculosis. We therefore supposed that the virus, rendered still 

 more virulent by its passage through the horse, would have developed 

 in the fowl, but in this case again inoculation was unsuccessful, the 

 fowl, on being killed at the end of 135 days, showing no appreciable 



lesion. 



DOG. 



Pulmonary tuberculosis. 



January 5th, 1891. 



\ 



III.' 

 Guinea-pig. Guinea-pig. Fowl.* Fowl. 



Died February 13th Died February 23rd Killed April i6th Killed July 19th (195 



(39 days). (49 days). (loi days). days). 



Generalised tubercu- Generalised tubercu- No lesion. No lesion. 



losis {liver, spleen, losis {liver, spleen, 



and lungs). and lungs). 



