THE TREATMENT OF TUBERCULOSIS. 599 



mortem examination showed hepatic and splenic lesions of an even 

 more marked character than in the first subject. The liver was 

 enormous, yellowish in colour, and crammed with tubercles. There 

 were numerous pulmonary granulations. 



Although these results were discouraging, the injections were con- 

 tinued until the loth October. At this time both the animals treated 

 and the controls were very thin. The investigation was terminated 

 by killing the surviving guinea-pigs. All showed tuberculous lesions, 

 and except in the case of two guinea-pigs belonging to the second 

 group, treated by subcutaneous injections, these lesions were more 

 intense and more generalised in the animals which had been injected 

 than in the controls. 



The parotid saliva of the horse has no attenuating action in vitro 

 on Koch's bacillus. M. Cadiot mixed lOO minims of saliva with a 

 quantity of the same tuberculous culture as was used for the preceding 

 experiments. After three days of contact, during which every pre- 

 caution was taken to avoid changes in the emulsion, it was injected 

 into the peritoneum of two guinea-pigs. At the same time a portion 

 of the culture equal in quantity to that which had been added to the 

 saliva was saved, and having been emulsified in a little sterilised water 

 was injected into the peritoneum of two other guinea-pigs. The four 

 animals were killed at the end of forty days and showed tuberculous 

 lesions of the liver, spleen, and lungs. In the first two peritoneal 

 granulations were found, but in the others nothing abnormal was 

 discovered. 



