6o2 CLINICAL VETERINARY MEDICINE AND SURGERY. 



the 23rd there was discharge from both nostrils ; respiration was painful 

 and wheezy. The animal died on the 27th ; weight of the cadaver ten 

 ounces. It had been injected six times, and had received in the sub- 

 cutaneous connective tissue of the abdomen five and a half fluid 

 drachms of serum. 



Autopsy. — The ulcers in the flank and the enlarged precrural lym- 

 phatic glands were connected by a fine knotted lymphatic cord. An 

 abscess the size of a haricot bean had developed in the thickness of 

 the abdominal wall at the point where the injections had been made. 

 Granulations and a few purulent nodules were present in the liver, 

 spleen, and lungs. There was suppurative orchitis on the left side, 

 acute inflammation of the peritoneal covering of the cord. The upper 

 portion of the vaginal sheath was obliterated by an extensive fibrous 

 exudate. 



(2) Male guinea-pig, weighing fourteen ounces, inoculated on the 

 23rd September. On the ist October the point of inoculation showed 

 a large bright red indurated patch. On the 4th a grey, cupped ulcer 

 had developed ; the margins, from which the hair had fallen, were 

 whitish in colour. Enlargement of the precrural glands as large as 

 a pea. 



First inoculation on the 5th October. On the i6th the ulcer in 

 the flank was slightly enlarged, and the precrural glands formed a 

 swelling the size of a haricot bean ; weight twelve ounces and a quarter. 

 On the 25th the appearance of the ulcer in the flank had improved ; 

 its borders were less red and hard. The right testicle was inflamed. 

 On the 8th November a cutaneous ulcer appeared towards the centre 

 of the dorsal region. On the 22nd this ulcer and that in the flank 

 were healing. The orchitic swelling was as large as a hazel nut. 

 Died on the loth December. Weight of the cadaver ten ounces 

 and three quarters. This guinea-pig had received nearly eight fluid 

 drachms of serum in eleven injections. 



Autopsy. — The ulcer in the flank had healed ; that on the back only 

 measured one sixth of an inch across. There was generalised inflam- 

 mation of the lymphatic glands, the centres of which were caseous. 

 The liver contained some purulent nodules ; the spleen was enormous, 

 weighing one and a quarter ounces, and was bosselated with nodules 

 and caseous centres. Three or four small pulmonary tubercles. Sup- 

 purative orchitis. 



Nine other guinea-pigs, inoculated by scarifying the skin of the face 

 and applying glanders pus obtained from the horse, were treated 

 with serum from turkeys injected with mallein, and afterwards with 



