INTRA-VENOUS INJECTIONS OF IODINE. 6ll 



38*4° C. ; pulse 39 ; respirations 11 ; ptyalism and trembling continued ; 

 signs of depression became more marked ; fresh passage of soft excre- 

 ment. At 5 p.m. temperature 38'!° C. ; pulse 45; respirations 13; 

 passage of large quantities of haemoglobinuric urine ; the depression, 

 salivation, and trembling fits were diminishing. At 6 p.m. temperature 

 38-4° C. ; pulse 47 ; respirations 11 ; still a few trembling movements. 

 At 7 p.m. temperature 38*4° C. ; pulse 52 ; respirations 14. The animal 

 seemed to have resumed its normal condition. 



(ii) Horse, weighing 594 lbs., received at i p.m. on the 29th March 

 an injection into the jugular vein of twenty-four fluid drachms of a 5 

 per cent, iodine solution (containing 64*5 grains of iodine, i. e. a little 

 less than •12 grain per pound of body-weight). Before the injection 

 temperature 38"i° C. At the end of three minutes defaecation ; a 

 quarter of an hour later salivation, attempts to vomit, rapid breathing ; 

 twenty minutes later excitement and signs of colic. At 2 p.m. pt3'alism 

 continued, and the animal attempted to vomit ; softened faeces were 

 passed ; temperature 38*5° C. From the second to the fourth hour 

 trembling and signs of depression ; temperature 39'i° to 39*8° C. At 

 5 p.m. passage of haemoglobinuric urine. After 6 p.m. the disturbance 

 diminished. There was no after complication. 



Introduced into the blood-stream in doses of "007 grain per pound 

 of the animal's body-weight {i. e. six grains for a horse weighing 

 880 lbs.), with the addition of sufficient iodide to dissolve it, iodine is 

 well tolerated and produces no manifest external symptoms. In doses 

 of '014 grain per pound (twelve grains for a horse weighing 880 lbs.), 

 whatever the degree of dilution, it usually produces more or less pro- 

 nounced symptoms, depending on the species of animal and on its in- 

 dividual susceptibility, symptoms among which ptyalism, trembling 

 fits, and localised convulsions are the most constant. Injection of 

 larger doses is only justifiable if immediate intense action is necessary, 

 if the doses can only be given at intervals of several days, or can only 

 be repeated a few times. 



In doses of '07 grain (60 grains for a horse weighing 880 pounds), 

 iodine produces grave disturbance, symptoms of hsemoglobinuria, and 

 very frequently renal lesions similar to those of haematuria. 



In my therapeutic experiments I did not exceed doses of 7 to 30 

 grains per day according to the weight of the horse. 



According to some authors iodine when injected into the blood can 

 have no useful effect because it combines wdth alkaline substances. It 

 would, therefore, have no action on micro-organisms, to destroy which 



