6l2 CLINICAL VETERINARY MEDICINE AND SURGERY. 



such large quantities would be required as to cause death from acute 

 iodism. In attacking the microbe one would destroy the cells and kill 

 the animal. But in refutation of this we urge that iodine, like the 

 iodides and other antiseptics, may prove valuable in toxi-infections 

 without actually destroying the microbes. Small quantities of anti- 

 septics and other chemical agents may act either by diminishing the 

 production of microbic poisons, by assisting in their destruction by 

 the organs, or by stimulating the emunctories ; or again, by exciting 

 the tissues to greater action, modifying the fluids of the body, and 

 rendering them less favourable to pathogenic agents. From this point 

 of view intra-venous injections of certain antiseptics seem capable of 

 varied apphcation. Only to mention one, if the reported cases of 

 recovery from glanders after intra-tracheal injections of iodine are 

 authentic — I especially allude to those of Chelchowski and of Neimann 

 — intra-venous injections of similar solutions deserve trial in horses 

 which mallein shows to be suffering from internal glanderous lesions, 

 and which sometimes have to be kept under observation for mouths. 

 As the specific lesions from which they suffer often end by spontaneously 

 healing, it is conceivable that one might assist the organism in its 

 struggle against infection and help it to emerge triumphant. 



Many other drugs may also be given intravenously with advantage ; 

 thus intravenous injections of argentum colloidale Crede in doses of six 

 to twelve grains dissolved in ten to thirteen fluid drachms of water have 

 proved of remarkable value in purpura hsemorrhagica of the horse 

 (Dieckerhoff, Meissner, Kroning) and in gangrenous coryza in the ox 

 (Meissner, Tannebring, David). 



In a similar way chloride of barium has been administered to 

 produce rapid evacuation of the bowel w^hen treating colic in the horse. 

 Despite the accidents which have followed administration of excessive 

 doses, or in which the animals were already intoxicated by intestinal 

 poisons, many practitioners continue its use. Syncope is avoided by 

 injecting small doses at intervals of fifteen to twenty minutes, as I 

 suggested in 1897. The first dose injected should be from three and a 

 half to nine grains, which may if necessary be repeated in fifteen to 

 twenty minutes. 



In animals intra-venous injection is very simple, though it requires 

 a little practice. As a rule the substance employed is very active, the 

 quantity of liquid injected small, and no special instrument necessary; 

 a syringe of six fluid drachms capacity and a needle about three inches 



