106 GLANDERS AND FARCY. 



sore of tlio nasal septum, while, if the inoculation is success- 

 ful, the specific lesions may be indifferently on the nasal 

 membrane, or in connection with the lymphatics of the extre- 

 mities. 



When referring to the history of glanders, it was noticed 

 that different ideas had, at different times, been held by all 

 who had paid more than passing attention to the disease. By 

 many of our most able investigators in the field of compara- 

 tive pathology, as Villemin, Roll, Falke, and some others, it has 

 been looked upon in all pertaining to its characters, causation, 

 sympt-oms, etc. — in truth, to its essential nature — as certainly 

 analogous to, if not identical with, tuberculosis or scrofula. 

 This relationship we cannot admit, as both its genesis and 

 entire clinical history clearly indicate that it possesses an 

 individuality and specificity entirely its own. By Virchow it 

 is placed amongst those diseases commonly described as 

 ' granulomes,' or granulation tumours, it being regarded as a 

 diseased condition having a tendency to the formation of 

 granular cells and minute tissue disintegration, or local de- 

 structive processes. While the ultimate cause of these minute 

 or elemental changes is regarded as intimately associated with, 

 or probably resulting from, some alteration in the nutritive pro- 

 cesses carried on in the tissues, the local capillary embolism 

 and phlebitis being in all these cases regarded as closely bound 

 up with this perverted nutrition tissue-decay, and death. 



Again, it is particularly to be observed that in the acute 

 form glanders has a great resemblance to pyaemia or septi- 

 ca3mia ; and by many has been regarded as the true repre- 

 sentation, in the horse, of these generally recognised morbid 

 states of the blood. 



Although certainly differing from these pathological con- 

 ditions in which the degraded and infecting products of 

 inflammatory action are present in the circulation, there 

 is little doubt that the blood is in a diseased condition, 

 seeing we know by experimentation that it contains the actual 

 and active morbific agent of the disease ; and thus we have 

 little difficulty to understand, so far, that healthy nutrition is 

 incapable of being carried on for any time, and that with im- 

 pairment or arrest of healthy nutrition we have molecular or 

 systemic death. 



