MODES OF PROPAGATIOX. 117 



infinitely less certain than through other channels, and 

 jjrobably in some animals is not in this manner capable of 

 entering the economy at all. 



Seeing that the possibility of developing the disease through 

 means of the introduction into the intestinal canal of matter 

 containing the specific discharges is a question of great sanitary 

 importance, and has large practical bearing, and knowing that 

 many even now have grave doubts of this possibility, I will 

 quote somewhat in detail one of several experiments carried 

 through under the direction of my predecessor. Professor 

 Simonds. 



' May 10th — Gave a donkey at 4 p.m. a quantity of glan- 

 derous matter mixed with Avater. The matter was two days 

 old, and had been obtained from a horse killed while affected 

 with glanders. May 12th — Animal apparently well ; tempera- 

 ture 100° F. ; 13th, temperature 103° F. ; 14th, temperature 

 ]04-3° F. ; 15th, temperature 1032° F. ; 16th, temperature 

 103° F. At this latter date the animal is reported as not 

 feeding so well ; it is also often heard coughing, and frequently 

 observed lifting the right hind leg. May 17th — Temperature 

 105-2 F., appetite very fastidious, pulse 64 per minute, animal 

 dispirited May 18th — Temperature 101° F.; 19th, temperature 

 98° F., scarcely takes any food, very dispirited, frequent lifting 

 of hind legs. May 20th, temperature 104° F., depression great, 

 no appetite, lymphatic glands under the jaw on the left side 

 tender and slightly swollen, lifting and abducting both hind 

 hmbs now present ; 21st, temperature 104-2° F., general symp- 

 toms the same ; 22nd, temperature 103° F., nasal discharge, 

 mucous and white ; 23rd, nasal discharge, copious from both 

 nostrils, sinking from choking produced by nasal obstruction, 

 temperature 100° F. ; 24th, autopsy : tuberculous deposit 

 extensively distributed throughout nasal passages, producing 

 great thickening of membranes, which were highly injected. 

 The specific deposit extended into the fauces and commence- 

 ment of the pharynx ; ulceration existed at several distinct 

 spots of the membrane, covering the deposit, but no indication 

 of this change on other parts of the structure : epiglottis and 

 surrounding parts inflamed ; no inflammation of great air 

 tube ; lungs a mass of tuberculous deposit ; lymph vessels and 

 glands in different situations indurated and enlarged.' 



