124 GLANDERS AND FARCY. 



dry, staring, and unthrifty condition of the coat ; the \)uhe is 

 increased in frequency, quick, soft, and of httle vohime ; the 

 respirations become frequent, and the temperature rapidly 

 rises and remains high, often standing for several days at 

 107° F. 



The animal is much distressed by enforced movement, the 

 breathing becoming rapid and s23asmodic, disturbed or snuffling, 

 indicative of infiltration in the submucous tissues of the upper 

 air-passages. The secretion of urine is often — not always, and 

 generally when the constitutional symptoms have somewhat 

 abated — augmented, clear and watery-looking, containing an 

 extra amount of albumen or albuminoids. 



There is much exhaustion and great emaciation. The visible 

 mucous membranes are much congested, the membrane of the 

 nose of a swollen hyperremic condition, at first of a yellowish 

 or straw colour, shortly becoming darker. In the course of a 

 few days, from three to five, there is generally a defervescence 

 of the pyrexial symptoms, which, however, return at a variable 

 interval ; with this remission of the fever, there is the develop- 

 ment of the specific local lesions. 



Over the surface of the pituitary membrane, most fre- 

 quently over that in the nasal septum, and at the ake of the 

 nose, Ave see small nodules or tubercles, either in groups, or 

 scattered less thickl}^ ; or in some instances there is a diffuse 

 elevated condition of patches on the membrane of a yellowish 

 colour, as if the epithelial covering was raised by subjacent 

 infiltration. 



The nodules or tubercles, varying in size from a large join's 

 head to that of a hemp-seed, appear as projections on an elevated 

 and injected base or background, and are rendered visible by 

 the white or yellowish- white centre. This centre is surrounded 

 by a greyish transparent zone, which again is encircled by a 

 red areola. 



In a few days from their first appearing, these papules soften 

 and disintegrate on their centres ; the larger diffuse infiltrated 

 patches also undergoing a similar change. 



The removal of the epithehal covering results in the 

 production of the characteristic chancrous sore or ulcer ; this 

 sore is marked by the possession of irregular excavated edges, 



