128 GLANDERS AND FARCY. 



nodules is in all essentials similar to Avliat was described in 

 the acute form. 



Their further development from the stage of nodulation, 

 and their destruction of tissue by ulcerative invasion, pro- 

 ceed and are accomplished by processes analogous, but only 

 less active, to those exhibited in acute glanders. The larger 

 eroded cavities, which result from extension by circumfe- 

 rential invasion of tissue, or by coalescence of original sores, 

 whatever may be their shape — and it is often very irregular 

 — always possess the same generic features of the smaller and 

 original chancres, the eroded base and slightly swollen or 

 everted edges. 



Both upon the edges of these larger excavations and upon 

 their base or floor, new nodules or tubercles similar to the 

 original arise, which by the carrying out of the disintegrative 

 changes and removal of destroyed tissue rapidly extend the 

 area of the sore. As these sores extend, the amount of 

 secretion naturally increases the discharge, seemingly ex- 

 cessive, when the extent of the suppurating surface is 

 regarded. The puriform secretion is generally spread over 

 the surface of these tumitied and vascular-looking ulcers, as if 

 for a protection, forming a loosely adhering yellowish-coloured 

 crust, tinged with blood. 



In addition to this disintegration of tissue and formation of 

 chancrous sores, another form of lesion is occasionally 

 observed in connection with the membrane of the nasal 

 septum. It consists, not in papules or erosions of the texture, 

 but appears to the eye as mere abrasion or denudation of the 

 parts affected of the entire epithelial covering, this denudation 

 extending no deeper than the superficial covering of the 

 membrane, but occu]3ying a considerable space. The place 

 of the removed epithelium is apparently supplied by soft 

 granular material, which is readily removed by passing the 

 finger over the part. 



The removal of epithelium is not, however, the earliest ap- 

 pearance of this condition ; it is rather a sequel. The first is of 

 an opposite character, in which the membrane seems to suffer 

 from an ordinary inflammatory action, is slightly exuberant, 

 and swollen from infiltration by a pale gelatinous fluid amongst 

 the interstices of the connective tissue. The result of this 



