SYMPTOMS OF CHROXIC GLANDERS. 129 



intiltration of fluid and varied forms of cell-growth is the 

 displacement of the entire epithelium, which previous to 

 removal is elevated and heaped together, giving that soft 

 granular character to the structure which has been noticed 

 as evident when touched with the finger. 



This process, and the peculiar results of it as regards the 

 infiltration of low cell-growths and accompanying products 

 prone to change and removal, bear a considerable resemblance 

 to the ordinary diphtheritic inflammation of mucous mem- 

 branes. This erosion of superficial structures may not be 

 seen in every case, but it has for long been observed in many 

 which have existed for a lengthened period. It has in this 

 form been spoken of as ' Inflammatory glanders,' ' Infiltrated 

 glanders,' and ' Diffuse glanders ' (Bollinger and Roll). 



Certainly this is not the same condition of the membrane 

 which is seen after extension and development of the primary 

 sores resulting from the rupture and softening of the nasal 

 papule or tubercle. These may be seen at the side or around 

 this abraded space, which, however, does not owe its existence 

 to the removal of the superficial tissue in the way indicated in 

 the case of these nodular changes and softenings, but to the 

 process of infiltration by products seemingly the result of 

 specific inflammatory action, or possibly having a close con- 

 nection with the condition of thrombosis of both venous 

 capillaries and minute lymph- vessels, which in such cases is 

 found pretty well established in these situations. 



Neither the large irregular-shaped rodent ulcers, the smaller 

 and shallower chancre sores, nor yet the diffuse superficial 

 erosions of which we have last spoken, are in ordinary cases 

 disposed to heal ; rather are they disposed to progress, the 

 ulcerative and destructive process not resting with the mucous 

 membrane or its subjacent tissues, but in course of time 

 invading the harder structures, the cartilage and bone. 

 Occasionally it may be observed, however, that some of these 

 ulcerative or abraded surfaces, by a changed, more active, and 

 reparative process, lessen in depth and superficial extent, 

 gradually healing over in an unique manner by the develop- 

 ment in the vacuities of cicatricial or fibrous tissue. The 

 cicatrix thus formed, when perfect, is sometimes slightly 

 depressed where the depth of the erosion previously existed, of 



9 



