68 Veterina}y Medicine. 



In mice subcutaneous injections proved fatal in five days with 

 general dissemination of the bacillus. There are congested and 

 hemorrhagic spots on the lungs, enlarged spleen, and the liver is 

 marbled by numerous necrotic white masses, in the centre of 

 which the capillaries are found to be blocked with the bacilli. 

 This is so pathognomonic that Loffler looks on the inoculation of 

 mice as the best means of diagnosis. 



Inoculated rabbits showed inflammation in the seat of inocula- 

 tion and sometimes fibrinous peritonitis and enlarged spleen. 

 Inoculation on the cornea produced a false membrane. 



In Guinea pigs induration and ulceration occurred in the seat 

 of inoculation but recover}' followed in 14 days. 



Sparrows inoculated in the pectoral muscles died in three days 

 with yellowish necrotic tissue highly charged with bacilli. 



Inoculation of the chicken b}- L,offier and Megnin produced 

 a circumscribed redness which soon disappeared. On the other 

 hand Krajewski, Colin, Loir and Ducloux .seem to have inocu- 

 lated chickens successfully, and Cadeac sa^'s that the cultures 

 are infecting for sparrows, pigeons, turkeys, chickens and 

 ducks. It rests uncertain therefore wliether the pseudomem- 

 branous pharyngitis of hens is a distinct disease as alleged by 

 Ivoffler and Megnin or if the chickens used by these observers 

 were not already immune by reason of a prior attack. 



Loffier's experiments showed that dogs and 7'ats were immune. 

 Ivoir and Ducloux failed to infect cattle. 



In infected dove-cots a comparative immunity is attained b}' 

 the older pigeons, which continue to harbor the germ, but do not 

 suffer materially from its presence. They however communicate 

 it to the susceptible young in the milky .secretion produced in the 

 crop and with which they feed them, and these accordingly perish 

 in large numbers. Thus pigeons that are themselves in fine condi- 

 tion become the propagators of the bacillus to the more impressible. 



Sparrozvs and other small birds are also held to be connnon propa- 

 gators of the germ, and if they too can secure an individual 

 immunity and yet harbor the bacillus, their passage from yard to 

 yard may be attended with great danger. The grains soiled by 

 their bills and not swallowed are common media of transmission. 



Loir and Ducloux found the affection transmissible between 

 man and pigeon. The identity of the bacillus with that of 



