426 Veterinary Medicine. 



lu^er. In one case, reported by St. Cyr, tlie liver was hyper- 

 tropliied, yellow, mottled, marked by irregular elevations of con- 

 gested and liypertrophied hepatic tissne, and showing extensive 

 degeneration — mucons, caseons and fatty. Thiernesse found the 

 liver of a yelhnvish white color, and the seat of fatty degenera- 

 tion implicating the liepatic cells. Franzenberg in one case 

 found fatty degeneration of the liver, and Frohnerand Schindelki, 

 in four cases, met with extensive hepatic disease. The macro- 

 scopic lesions of the disease in dogs as in horses appear to be 

 mainly hepatic. 



On the other hand the complete removal of the pancreas in the 

 dog by Mering, Minkowski, Thiroloix, Lancereaux and other.s 

 was invariably followed by mellituria, so that even in the absence 

 of clinical examples, we must recognize pancreatic lesions and 

 functional disorders as possible primary causative factors in gh'- 

 cosuria. In the light of experimental medicine we must similarly 

 recognize brain and nervous lesions and reflex actions as possible 

 causes, even if as yet unsupported by clinical facts observed in 

 the dog. 



Symptoms. The disease usually appears in an old, fat, pam- 

 pered dog, affected with dyspnoea or asthma, with dysuria and 

 lameness. The urine is high colored, viscid, and of a high 

 densit}' (1055 to 1060, the normal canine urine being about 

 1020), and charged with glucose. The sul)ject may have an 

 enormous appetite but fails to gain in weight, and after a time 

 loses flesh and becomes badly emaciated. The pulse is small 

 and frequent, and the temperature which at the outset may 

 reach 102°, falls to the ucjrmal as the end approaches. Watering 

 eyes, corneal ulcers, and cataracts as well as hemiplegia and dia- 

 betic coma may precede death. The amount of sugar has been 

 found to vary in different cases from 3.2 to 12 per cent, of the 

 urine. 



Course. Duration. The dog may live from four to eight 

 months and, as in the horse, sugar may finally entirely disappear 

 from the urine, in connection with the progressive degeneration 

 of the liver. If the patient is unable to take exerci.se, the case 

 reaches a more speedily fatal issue. 



Diagjiosis is deduced from the bulimia, pampered condition, 

 breathlessness, thirst, and diuresis, the subsequent loss of condi- 



