34 2 Veterinary Medicine. 



cow. Most of those so inoculated had unmistakable smallpox 

 and three died. 



Reiter had a vety similar experience. 



Chauveau (French Commission) inoculated twelve susceptible 

 cattle with smallpox virus and produced, in all but one, small 

 conical (smallpox) papules and vesicles, and in ten of these, on 

 subsequent inoculation with cowpox, six proved immune, three 

 had rudimentary pustules, and one had a distinct cowpox erup- 

 tion. 



A milch cow and two heifers were inoculated with smallpox 

 and cowpox on two sides of the vulva, with the result that each 

 disease appeared in the seat of its inoculation, with its character- 

 istic vesicles, and the two developed side by side. The smallpox 

 vesicles were by inoculation conveyed from ox to ox with steadily 

 decreasing activity. Inoculated from the cow on a child, it caused 

 great hyperthermia, vomiting, one large vesicle like vaccinia and 

 a general eruption like varioloid. Inoculation from this child 

 upon another produced a mixed eruption of cowpox and varioloid. 

 Inoculation from the second child on a bull and heifer produced 

 papular eruption only. 



Smallpox virus, inoculated on a horse produced a papular erup- 

 tion, but failed to affect another horse that had been previously 

 vaccinated. Cowpox virus inoculated on the first horse which 

 had had the papular eruption, caused a second papular eruption 

 (not cowpox). The virus from a vesicle in the first horse caused 

 a similar eruption in another horse, on which it was inoculated. 

 The lymph from the papular eruption led to a similar eruption in 

 cattle, on which it was inoculated, but did not protect against 

 cowpox, subsequently inoculated. 



The lymph from the papular eruption in the horse, inoculated 

 on two children, produced fever, vomiting, a general papular 

 (smallpox) eruption, in which a few of the pustules only showed 

 a tendency to umbilication. A child and its mother in the same 

 ward contracted varioloid. A child inoculated from one of the 

 first named children, had six large umbilicated vesicles like cowpox 

 and a general papular (smallpox) eruption. Another child inocu- 

 lated from the last had six large umbilicated vesicles, and a gen- 

 eral papular (smallpox) eruption. From the papular eruption of 

 one of these children a horse and seven cattle were inoculated and 

 in all a varioloid eruption resulted. 



