D oarine. 529 



suspicious animals all mares that have been served by a stallion 

 which is in the line of infection. This suspicion would attach 

 also to any stallion that had served a mare which had been to a 

 diseased or suspected stallion, and to all mares that have been 

 served by the suspected stallion after he had been to the sus- 

 pected mare. 



From simple vesicular exanthema dourine is to be distinguished 

 by its comparatively slow progress, and by the uniformity of the 

 lesions of the generative organs and nervous system, which are 

 lacking in the vesicular affection. 



Prognosis. A certain number of animals recover from the 

 milder attacks which have not become complicated by the grave 

 trophic and nervous lesions, but as in glanders, recovery from 

 severe attacks and in the advanced stages is practically unknown. 

 The mortality is set at 70 per cent, and upward. 



Symptoms in the Ass and Mtile. The disease usually remains 

 discrete, the lesions in the generative organs or other seat of in- 

 fection being the marked symptoms, and recovery the rule. 

 CEdema of the end of the penis, obliteration of the folds around 

 the orifice of the urethra and eversion of the urethral mucosa are 

 the most constant features, distinct even in semi-erection. CEdema 

 of the sheath and skin eruption may follow. Exceptionally a 

 mule proves as susceptible as the horse, and shows the disease 

 with the same fatal severity. 



Symptoms in Dog. A bitch, 15 days after vaginal injection 

 of the infected equine blood, showed severe vaginitis and hyper- 

 thermia (ioo°). On the 23d day she aborted, followed by muco- 

 purulent discharge, vulvar oedema, pallor of the mucosae, 

 anaemia, rapid emaciation, paresis and occasional convulsions. 

 Blood drawn from the vulva contained the trypanosoma. She 

 died on the 66th day. The temperature rose to 103 . 



Two male dogs that lined the above infected bitch showed after 

 12 days, engorgement of the sheath and scrotum, muco-purulent 

 discharge, and abundance of the trypanosoma in the blood of the 

 affected parts. Cutaneous lesions on the loins, thighs, sides or 

 forehead, showed erection of the hair, with infiltration, or 

 shrivelling and bloodlessness. 



Other dogs showed arthritis, corneal opacities and ulcers, 

 34 



