31 



Calcareous nodules were also occasionally found in 

 the liver and spleen ; these were also frequently 

 examined and experimented with, but as glanders was 

 in no case proved, or detected, it was concluded they 

 were due to other causes, e.g.^ of vegetable or parasitic 

 origin. 



Diagnosis 



Under this heading I don't think that I can do 

 better than quoting first Nocard and Leclainche, 

 who state that the ulcer of epizootic lymphangitis is 

 frequently typical, and is characterized by its exuberant 

 granulations, its bright red colour, its inverted edges, 

 and its thick creamy discharge of pus, in fact the 

 appearances are all quite different from those of 

 glanders, although in old cases they are less 

 characteristic. 



However, as long as any doubt exists as to the 

 correct diagnosis, it is advisable to have recourse to all 

 the available experimental methods in order to arrive 

 at an undisputable conclusion. 



Examination of the pus gives a certain and 

 immediate diagnosis. The cryptococcus is said to be 

 easily seen without staining with a magnifying power 

 of 400 to 500 diameters, but personally I like a power 

 of not less than 800 diameters for unstained specimens ; 

 the organism is recognized by its size, shape, and 

 highly refractory double outline. 



The parasites are almost as easy to find in a 

 scraping of mucous membrane or tissue, but are 

 generally not so numerous there as in material from a 

 fresh pustule. 



Careful mallein testing should in no case be 

 followed by a re-action, except when glanders is 

 co-cxi stent. 



