2V8 THE AMERICAN MONTHLY fSept 



larger than iu the tertian, irregular, with but little if 

 any movement. In the aestivo-autumnal form the pig- 

 ment is active, although some describe it as slight, at first 

 fine, later course, even rodlike. 



Size. — The tertian is as large as the red blood disc, 

 even larger; the quartan not larger than the red corpus- 

 cle, while the tropical forms are much smaller, from 1-5 

 to I the size of the hemacyte. 



Protoplasm of the Parasite. — In the tertian it is 

 pale and indistinct; in the quartan, sharply outlined, and 

 of a characteristically high index of refraction; in the 

 autumnal type it is ringlike, very small, hyaline, and 

 difficult to detect. 



Alteration in the Red Blood Cells. — In the ter- 

 tian the red blood cells hypertrophy, and are rapidly 

 and completely decolorized. In the quartan they are 

 but little decolorized, may be darker than normal, and are 

 not essentially altered in size, although the corpuscle 

 may become slightly smaller than normal. In the more 

 pernicious types they are shrunken, become either darker, 

 of "brassy" color, or completely decolorized, "shadow- 

 like." 



Sport lation form. — In the tertian the spores are more 

 or less irregularly grouped, individually small, round, 

 whose nucleolus is seldom seen in unstained specimens, 

 numbering 15 to 20 or somewhat less. The segmenting 

 forms are about the size of a red disc, and are of irregu- 

 lar form. The segmenting bodies are found in the peri- 

 pheral Mood rarely, or in small numbers only, except at 

 the time of a paroxysm. In quartan malaria the spores 

 exist in the margarite form, spores being individually 

 long, with distinct nucleolus, 6-12 in number. The seg- 

 menting forms are smaller than a red blood corpuscle, of 

 a rosette form, are found in equal numbers in the peri- 

 pheral and visceral circulations, and may l)e detected in 

 the apyretic interval as well as in the paroxysms. In the 



