GLANDERS AND FARCY. 265 



■wound is sufficient to inaugurate the acute course or a rapid progress of 

 the morbid process. 



2. If ghxuders has been communicated by a direct introduction of 

 glanders-matter into a wound, or a direct contact of the contagion with 

 the blood. The greater the quantity of glanders-matter introduced the 

 more concentrated the contagion inoculated, or the larger the wound 

 the more acute or rapidly progi'essing and spreading is usually the 

 morbid process of the commuaicated disease. 



3. If the constitution of the animal has been weakened, or if the 

 vitality of its organism has been seriously impaired either by glanders 

 Itself or by any other disease, the course of glanders, although natu- 

 rally slow or chronic from the beginning, is usually changed to an acute 

 one as soon as the morbid changes have become sufficiently important 

 and extensive to weaken essentially the constitution of the animal, and 

 to cause a profuse infection or spreading of the contagion through the 

 lymphatics in the animal organism. Toward its fatal termination 

 glanders, therefore, always changes its course from chronic to acute. 

 Unhke most other diseases it commences chronic and ends acute. 



4. Exposure to wet, cold, and inclement weather, catching cold, hard 

 work, close, dirty, and ill-ventilated stables, unhealthy food, &c. — ^in 

 short, everything that is calculated to i^roduce an injui-ious influence 

 upon the organism, or is calculated to impair the health of the animal, 

 has a tendency to accelerate the morbid process, to change the chronic 

 course of glanders to an acute one, and to hasten the outbreak after an 

 infection has taken place. 



The morbid ])rocess of glanders is accelerated and caused to spread 

 more rapidly if the latter becomes complicated with an inflammation, 

 or with any very feverish or very tyi^hoid disease. The morbid pro- 

 cesses of glanders and inflammation increase each other reciprocally. 

 The inflammatory process adojits, to a great extent, the nature and 

 characteristics of glanders, and the morbid process of the latter disease 

 becomes blended with the former, and assumes the attributes of an in- 

 flammation. In either case all the symptoms become very violent, and 

 the morbid process progresses and spreads very rapidly, particularly 

 in those tissues which are in a state of inflammation. Ulceration, too, 

 becomes extensive in a short time, and the lymphatics, by absorbing 

 the deleterious matter, seem to spread the contagion and the elements 

 of glanders rapidly through the whole system. If the original disease 

 is glanders, farcy will also make its appearance within a short time ; 

 and vice versa, existing farcy will soon be complicated with nasal and 

 pulmonal glanders of an inflammatory character. The exudations pro- 

 duced by an inflammation which has assumed the nature of glanders 

 are always very deleterious and corrosive and destroy like a caustic the 

 tissues with which they come in contact. The morbid changes eftected 

 by such an inflammation resemble .those of a malignant diphtheria. In 

 extreme cases the morbid process may become so violent as to cause 

 the neoplastic process, characteristic of glanders, to be superseded 

 by immediate destruction and mortification. In such a case profuse, 

 diphtheritic idceration and destruction of tissue take the place of the 

 neoplastic production of glanders-cells and their subsequent decay. 

 The glanders-cells are destroyed (decay or perish) before their forma- 

 tion has been completed, consequently are absent. 



That a direct and abundant introduction of glanders-matter into a 

 wound, or a direct contact of the contagion with the blood, is well cal- 

 culated to produce an acute form of glanders, or suliicieut to inaugurate 

 a rapid progress of the morbid process, is probably best illustrated by a 



