GLANDERS AND FARCY. 271 



and 4.) Such a production or development of glanders-cells just de- 

 scribed can take place in young' or inideveloped arid incipient epithe- 

 lium-cells, because round giant-cells tilled with nuclei and small round 

 cells are formed frequently in the deeper or youngest strata of the epi- 

 thelium. (Fig. Ill, Ko. o.) 



Wherever such a neoplastic growth is making its appearance the pro- 

 cess is always essentiallj^ the same. The original nuclei of the prinuuy 

 epithelium-cells and connective tissue-corpuscles increase in size, and 

 new nuclei are formed within the external membrane, or enveloi)e, of 

 the xnimary cells. These nuclei are transtbrmed into small round cells, 

 which are liberated by the decay of the old mother or brood-cells, and 

 constitute what is called daughter-cells, and grow larger. This growth 

 and development constitutes a characteristic peculiarity of the large 

 round glanders-cells, which distinguishes the same from otherwise shni- 

 lar granulation-cells, matter-corpuscles, and tubercle-cells, because the 

 latter, during their vrholo existence, remain unchanged at their lirst 

 stages of development. Although young glauders-cells are small, and 

 large ones old, the difference in size does not depend exclusively upon 

 the age of the cells. Other gTO\\i:h-promoting and growth-retarding in- 

 fluences must be existing, because some cells groM' faster than others, 

 and some do not seem to grow at all. Under certain circumstances only 

 small cells can be found, which are not different from common matter 

 corpuscles, and in other cases a great many large ones, sometiuies of an 

 extraordinary size, i)resent themselves. If the morbid process is a vio- 

 lent or a very rapid one, the glanders-cells are always small; rapid 

 development and a fluid intercellular substance constitute the agencies 

 which deprive the cells of their ability to grow, or cause them to remain 

 small, and of a souiewhat uniform size. Consequently, in all those cases 

 in which the morbid process of glanders is blended from the beginning; 

 with more or less inflammation and exudation, the glanders-cells wiU be 

 small and numerous ; and as the imflanimatory exudations destroy and 

 dissolve the intercellular substance, the latter and the exudations them- 

 selves will constitute a fluid in which the gla,nders-cells are kept sus- 

 pended. The glanders-matter thus formed does not present, under the 

 microscope, any characteristic differences from any other r.iatter or pus. 

 A production of glanders-matter and of numerous small glanders-cells 

 is comm.on if the neoplastic process has its seat in the subcutaneous and 

 intermus(;ular connective tissues consequent in farcy. In all those cases, 

 however, in which glandei's presents itself as a chrotiic disease, free from 

 any complications with inflammatory processes, <S:c., v/hatever, in which 

 the formation of the glanders-cells is a gradual siud slow one, and in 

 which the intercellular substance is not destroye<l aud dissolved, the 

 glanders-(;ells will grow to a, certain size, and young- cells with delicate 

 contours and large, bright nuclei, older and larger ones, and very largo 

 ones with dark-colored luiclei and granulated contents, Avill present them- 

 selves. 



The vitality of the neoplastic products ct glanders is limited, but dif- 

 fers considerably accordiiig to circumstances. The small, rai)id]y pro- 

 duced, and therefore nuinerous, cells, suspended in a dissolved intercel- 

 Inlar tissue aiul exudations, are siinilar in every respect to matter- 

 corpuscles ; the same not only do not grow, but shrink and decay very 

 soon. If the intercellular substance does not decay, but retains its 

 original comiective properties, the glanders-cells not only grow larger, 

 but also a groat deal older, than matter-cor])uscles or tubercle-cells. This 

 vitality will be the greater the larger the space or tiie greater the amount 

 of the connective intercellular substance between the single cells. Their 



