GLANDERS AND FARCY. 277 



very mncli swelled or just breaking, and others decayed and discliarg- 

 inij- tlieir c:raniilatcd contents and large nuclei, and a connective inter- 

 cellular substance wliicli gives the whole tumor its continuity and a cer- 

 tain degree of solidity, constitute the principal components. The softer 

 glanders-tumors, similar in consistency to a sarcoma, arc composed 

 mainly of round cells, while the liiiner or more solid ones consist prin- 

 cipally of spindle-shaped cells, and contain comparatively few round 

 cells imbedded in the intercellular substance, which latter is here and 

 there fibrous and solid, aud thereby the cause of the greater firmness. 

 The presence of both kinds of cells, spindle-shaped and large, round 

 ones, proves that connective-tissue corpuscles, as well as epithelium ele- 

 ments, contribute to the formation of pulmonal glanders-tumors. The 

 retrogressive metamorphosis proceeds, according to the observations of 

 Gerlach, in two different ways. Sometimes all components of the glanders- 

 tumor, the intercellular sul:)stance as well as the glanders-cells, undergo a 

 l)rocess of decay which j)roceeds either from one center — if the tumor is a 

 simi)le one — or from several centers simultaneously, if the tumor is a compli- 

 cated one. In the former case the whole tumor is changed to one cavity with, 

 cheesy contents, but in the latter two or more larger or smaller cavities, 

 corresponding to the number of the original tubercles or tumors, are 

 l^roduced. The contents of the same present also a cheesy appearance. 

 Sometimes, however, the whole process is different. The round-cells 

 decay and are absorbed, and an excessive growth or production of con- 

 nective tissue is taking place. The tumor becomes harder and firmer, 

 and assumes finally the characteristics of a fibroid growth, which con- 

 tains interspersed in its tissue a few round-cells, and may not undergo 

 any further changes for a long time. Such fibroid tumors correspond 

 to the fibroid cicatrices which occur frequently in the mucous membrane 

 of the septum, and are found not seldom if the morbid process has been 

 a very slow or chronic one. If glanders is acute or complicated with 

 other morbid processes which accelerate its progress, such hard and 

 firm fibroid tumors or cicatrices are never formed. On the contrary, 

 the glanders-tumors decay rapidly, often before the same have had time 

 to assume definite shape and form. 



Glanders-ulcers or abscesses are produced if the intercellular sub- 

 stance of the tubercles undergoes dissolution. Dissolved intercellular 

 substance and decayed and decaying glanders-ceUs constitute the matter. 

 The process is about as follows : 



Farcy-ulcers in the suhcutaneons connective tissue. — The development 

 or the growth of a farcy-tumor is always attended with some local in- 

 flammation in the surroimding tissues. A violent proliferation begins 

 in the center of the tumor, and numerous small round-cells which can 

 scarcely be discriminated from matter-corpuscles are produced. The 

 inflammatory process furnishes a sufficient quantity of exudation to 

 loosen and to envelope the round-cells almost immediately after the 

 same have been i^roduced. Some white blood-corpuscles may become 

 jntermixed, but the same nuist be regarded as strangers, because a very 

 large majority of the cells suspended in the fluid exudation are the pro- 

 duct of the proliferous process. So it may happen that a farcy boil or 

 tumor shows fluctuation, and contains matter within a few days, or is 

 changed to an abscess much sooner than a common boil. The matter 

 of a ftircy-ulcer does not exhibit any distiueti^'e dilference from other 

 pus except in so t\ir as it possesses infectious (|ualities. Almost as soon 

 as a farcy-boil has been changed to an abscess, or contains matter, the 

 nearest subcutaneous lymphatics commence to swell to plainly visible 

 chords or strands, and in their course not seldom new boils are formed, 



