TUBERCULOUS SERUM. 



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infiltration is much less, or entirely 

 absent, due, as a general rule, to the 

 fact that sensitization of bacteria 

 tends to neutralize those substances 

 which produce infiltrations. This 

 last has been demonstrated by the 

 author in cases of mouse-typhoid, 

 and swine pest bacilli, where marked 

 infiltrations following their inocula- 

 tion have by afore-mentioned means 

 of sensitization been avoided. The 

 following chart illustrates prelimi- 

 nary treatment with S. B. E. followed 

 by B. E. (Chart 4.) 



The patient was a female who at the 

 time of admission presented double-sided 

 apical pulmonary and suspicious intestinal 

 tuberculosis. Tubercle bacilli were present 

 in the sputum. The patient was dis- 

 charged from the clinic as relatively cured, 

 i.e., all manifestations of illness had disap- 

 peared with the exception of slight dulness 

 over one of the apices which, however, could have been attributed to cicatrization. 

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In respect to the objection frequently advanced that B. E. is absorbed 

 with difficulty and tends to produce 

 infiltrations, it may be remarked, 

 that this may be readily overcome by 

 preliminary use of T. R. or by the em- 

 ployment of sensitized B. E., as has 

 been advised by Meyer and Rupple. 



By sensitized B. E. is under- 

 stood, a bacilli emulsion which has 

 been mixed with the tuberculous 

 serum of a horse or ox containing 

 anti-tuberculin. This mixture brings 

 about a union between certain of the 

 antibodies and substances contained 

 within the bacteria. The tuberculous 

 serum is then removed by centri- 

 fugalization and washing of the mix- 

 ture with physiological salt solution. 



The sensitized B. E. (S. B. E.) is 

 milder than B. E. and in its character 

 otherwise more like T. R. The 



