ON NEURAL EXCRETION 83 



principle is the recognition of the fact that there can only 

 be in malignant disease, as in all disease, the collision or 

 friction of two factors, the material and dynamic, and a 

 resultant pre-pathological disturbance of, and disparity in, 

 the working of physiological organic statics and dynamics, 

 which may, or may not, lead to a sustained pathological 

 working of certain structures and organs, and to the estab- 

 lishment of fully evolved malignancy. The recognition, 

 therefore, of the circumstances constituting this premoni- 

 tory disturbance, disparity, and friction in the material and 

 dynamic working of the human organism, is the great end 

 to be aimed at primarily by research, as the prevention, and 

 not the cure of the disease, will then only have to be 

 dealt with, while the way to remedial success may simul- 

 taneously be brought into clearer view, if not practical 

 realisation. 



From all which it follows as axiomatic that, if the 

 physiological material and dynamic balance in the working 

 of the human organism can be constantly maintained, no 

 disease, innocent or malignant, can exist, and that, if 

 unhappily that balance is but temporarily impaired or 

 lost, it equally follows that disease is beginning, or has 

 begun, and that the incidence of that disease will depend 

 on the nature of the influence or influences by which the 

 balance has been destroyed, while the later stages of the 

 disease so commenced must be evolved by the vital con- 

 dition of its subject, and the character of the accessory 

 morbid influences and agencies, material and dynamic, 

 active and passive, live and dead, which are then naturally 

 present at, or subsequently determined to, "the scene of 

 operations." 



In the evolution of disease it must never be forgotten 

 that the two usually co-operating agencies, dynamic and 

 material, have for the time being ceased to work in har- 

 mony, with the result that the scene of their combined 

 operations ceases to be characterised by functional and 

 organic order and normal material disposition, and assumes 

 an appearance of spasmodic effort, in-coordinate and pur- 

 poseless, as to function and destruction of material or 

 structural integrity ; we will thus, on coming critically to 

 examine the "condition of things" brought about by this 



