210 PHYSIC 



we may be prepared to find that the textures involved in 

 the inoculation and absorption are undergoing a more or 

 less complete necrosis and disintegration at the affected 

 points, and that the disease is evolving from a local into 

 a general pathological condition, the prevention of which 

 latter occurrence ought, therefore, to be the aim of all well- 

 directed treatment. 



Should this unfortunate occurrence, the change from a 

 local to a general affection or disease, have been overlooked 

 or neglected, and the changes dependent on the further 

 development of the pathological phenomena constituting 

 the disease having been allowed to begin to display them- 

 selves, we shall now observe that the absorbents, as repre- 

 sented by the lymphatics, begin to display symptoms of 

 involvement, it may be, along the course of the nearest 

 lymphatic vessels and in the glands to which they lead 

 by a process of inflammatory engorgement and thickening, 

 a brawny swelling of the peri-lymphatic textures, and a 

 more or less conspicuous enlargement of the glands first 

 interposed in the lines of invasion. This condition is 

 known as bubo, and is due to the invasion of the matrix 

 of one or more of the lymphatic glands, of the groin by 

 preference, owing to the prevailing manner of infection. 

 Should this bubonic barrier arrest the progress of the 

 materies morbi and secure its removal from the system 

 before it has had time and opportunity to infiltrate and 

 infect it, then we are warranted in expecting an avoidance 

 of the long sequence of untoward events, consisting of 

 the secondary, tertiary, and consequential transmitted or 

 inherited stages of the disease. 



Should, however, this desirable arrest of the disease not 

 have been effected, and an entrance have been secured 

 into the body proper by the virus of the disease, then we 

 may expect the invasion in detail of all its parts, organs, 

 textures, and fluids, and the sapping of its health to its 

 "very foundations." 



The line of attack of the disease in this instance has 

 been by way of the lymphatics through imbibition of its 

 poison by the open mouths of its vessels or spaces, where 

 they lie exposed in the depths of the primary sore, and 

 where the culture of the lethal organisms or specific virus 



