2 6o PHYSIC' 



disposal of brain waste, and gives rise to symptoms due 

 to systemic invasion and local and general pseudo-organic 

 disposal of non-hygienic or effete plasma accruing from 

 the absence of the proper gland disposal by certain struc- 

 tures, such as the cutaneous and sub-cutaneous tissues of 

 the face and supra-clavicular regions, whose position, with 

 relation to the outflow of this material and the nature of 

 their anatomical structure, make them suitable dumping- 

 grounds and storage areas in such emergencies. 



A family relationship, in fact, on account of the position 

 and function of the thyroid gland in the work of pituitary 

 excretion, thus may be said to exist between such affections 

 as cretinism, myxcedema, and dwarfism, on the one hand, 

 and acromegaly and gigantism, on the other, which makes 

 more intelligible many of the likenesses and unlikenesses 

 that characterise this group of diseases, whose etiology is 

 so intimately associated with the negative and positive 

 aspects respectively of pituitary excretion and retention. 



