784 MICROBIOLOGY OF DISEASES OF MAN AND DOMESTIC ANIMALS 



The case history and lesions produced parallel very closely those pro- 

 duced by the Saccharomyces. This Sporothrix seems to have great 

 vitality, remaining virulent in dried pus at a temperature of 7 for 

 three months or more. 



The same organism has been recovered from similar lesions of the 

 human where it was apparently acting as the direct exciting cause. 

 If this be confirmed, we have two apparently different organisms cap- 

 able of producing a similar mycotic lymphangitis. Complement 

 fixation work by Meyer suggests that the two may be at least more 

 closely related than was previously supposed. 



DISEASES CAUSED BY BACTERIA* 



BOTRYOMYCOSIsf 



Micrococcus pyogenes 



We have typically in this disease closed abscesses with very tough 

 fibrous walls and slow development. These abscesses involve espe- 

 cially subcutaneous and intermuscular connective tissue, although 

 typical lesions have been found in various internal organs. 



This affection is probably limited to equines. The essential char- 

 acteristic of this disease is the presence of the peculiar masses of micro- 

 cocci (Bellinger's granules). This massing seems to occur only in 

 chronic cases where a certain degree of immunity has developed. 



The identity and proper classification of a specific microorganism 

 is still in dispute. Johne found M. ascoformans acting as an etiolog- 

 ical factor. Kitt and others found micrococci which could not be dis- 

 tinguished from M. pyogenes. Moore found a variety of pyogenic 

 micrococci and streptococci apparently serving as causative agents 

 and reports one case of an enlarged spermatic cord where he found a 

 fungus resembling Actinomyces boms. Others identify Botryomyces 

 equi as Staphylococcus pyogenes aureus, etc. 



Primary infection occurs by inoculation and not infrequently 

 follows surgical operations, e.g., castration. The primary infection 

 may then lead to involvement of internal organs by metastasis. The 

 local effect here is that of an irritant and both irritant and tissue 

 response appear to resemble those that occur in actinomycosis. 



* Arranged alphabetically under each of the following families: Coccacece (Micrococcus, 

 Streptococcus), Bacteriacece (Bacterium, Bacillus, Pseudomonas), Spirillacece (Microspira). 

 t Prepared by M. H. Reynolds. 



