868 MICROBIOLOGY OF DISEASES OF MAN AND DOMESTIC ANIMALS 



REFERENCES 



Sambon, Brit. Med. Journ., Nov. n, 1905; Journ. Trop. Med. and Hyg., 1910, 

 Vol. 13, pp. 271-282; 287-300; 305-315; 319-321- 



Billings and collaborators, Report of the Pellagra Commission of the State of 

 Illinois, Springfield, 111., 1912. -A condensation of this report appeared in Arch. 

 Int. Med., Aug. and Sept., 1912, Vol. 10. 



Sandwith, Trans. Soc. Trop. Med. and Hyg., 1913, Vol. 6, pp. 143-148. 



Siler, Garrison and MacNeal, First Progress Report of the Thompson-McFadden 

 Pellagra Commission, New York, 1913; Second Progress Report of the Thompson- 

 McFadden Pellagra Commission, New York, 1914; Third Report of the Robert M. 

 Thompson Pellagra Commission, New York, 1917. Individual papers constituting 

 the First, Second and Third Reports appeared in American Journal of the Medical 

 Sciences in 1913, in Archives of Internal Medicine, 1914, and ibid., 1916 and 1917. 



MacNeal, The alleged production of pellagra by an unbalanced diet, Jour. Amer. 

 Med. Assoc., Mar. 25, 1916, Vol. 66, pp. 975-977. 



Goldberger and collaborators, A study of the diet of nonpellagrous and of pella- 

 grous households, Journ. Amer. Med. Assn., Sept. 21, 1918, Vol. 71, No. 12, pp. 944- 

 949. Other references are given in this article. 



Jobling, Peter sen and collaborators, Journ. Infectious Diseases, 1916, Vol. 18, 

 PP- 501-567; ibid., 1917, Vol. 21, pp. 109-131. 



RABIES* 



Lyssa or Rabies, the madness of dogs, was recognized as a definite 

 disease of animals and man by the peoples of ancient times. The 

 disease is generally distributed throughout the civilized world except 

 in those places where special measures to stamp it out have been 

 enforced. It does not arise spontaneously but is an infectious disease 

 transmitted from animal to animal. Rabies is primarily a disease of 

 wolves and dogs, and the bite of a mad dog is the most frequent cause 

 of the disease in other animals and in man. It is not uncommon in 

 horses and cattle, and all mammals appear to be susceptible to it. 



In animals inoculated by injection of the most virulent virus (fixed 

 virus) directly into the brain, the symptoms of rabies appear in four 

 to six days and death usually occurs on the seventh day. Accidental 

 inoculation by the bite of a rabid animal (street virus) rarely causes the 

 symptoms to appear before three weeks, and the onset may be delayed 

 for six months or a year. Not all persons or animals bitten by rabid 

 animals take the disease; probably not more than one in four or five. 

 This variability depends upon several factors, the most important 

 ones being the virulence and the amount of disease virus, and the part 



* Prepared by W. J. MacNeal. 



