368 Suppuration 



Intraperitoneal injections cause purulent peritonitis. 



Blum* reports a case of pyocyaneus infection with endo- 

 carditis in a child. 



Lartigau,f in his study of " The Bacillus Pyocyaneus as 

 a Factor in Human Pathology," sums up what is known 

 about this role of the organism as follows: " The Bacillus 

 pyocyaneus, like many pathogenic micro-organisms, is 

 occasionally found in a purely saprophytic role in various 

 situations in the human economy. It has been found in the 

 saliva by Pansini, in sputum by Frisch, and in the sweat by 

 Kberth and Audanard. Abelous demonstrated its presence 

 in the stomach as a saprophyte. Its existence in suppurat- 

 ing wounds has long been known, and Koch early detected 

 its presence in tuberculous cavities, regarding it as an 

 organism incapable of playing any pathologic role. The 

 etiologic relation of the organism to certain cases of purulent 

 otitis media in children was pointed out by Martha, Mag- 

 giora and Gradenigo, Babes, Kossel, and others. H. C. 

 Ernst obtained it from a pericardial exudate during life. G. 

 Blumer demonstrated its presence in practically pure cul- 

 tures in a case of acute angina simulating diphtheria; 

 Jadkewitsch, B. Motz, and Le Noir obtained the bacillus 

 in cases of urinary infection. The cases of Triboulet, 

 Karlinski, Oettinger, Bhlers, and Barker are interesting 

 instances of its role in cutaneous lesions. 



" In addition to these lesions, other morbid processes 

 have been associated in some cases with the bacillus of 

 blue pus, such as meningitis and bronchopneumonia, by 

 Monnier; diarrhea of infants, by Neumann, Williams, Thier- 

 celin and Lesage, and other observers; dysentery, by Cal- 

 mette and by Lartigau; and general infection, by Khlers, 

 Neumann, Oettinger, Karlinski, Monnier, Krannhals, Cal- 

 mette, Finkelstein, and I,. F. Barker." 



Nine additional cases of human infection are reported by 

 Perkins. { 



Immunity. Immunity against pyocyaneus infection de- 

 velops after a few inoculations with attenuated or sterilized 

 cultures. These are easily prepared, the thermal death-point 

 determined by Sternberg being 56 C. It also follows in- 

 jection of either the endotoxin or the exotoxin. In the 



* "Centralbl. f. Bakt. u. Parasitenk.," Feb. 10, 1899, xxv, No. 4. 



t "Phila. Med. Jour.," Sept. 17, 1898. 



t "Jour, of Med. Research," vol. vi, 1901, p. 281. 



