42O 



Hydrophobia, Lyssa, or Rabies 



central canal of the cord, about the ganglionic nerve-cells, 

 and about the capillary blood-vessels, but that the lesions of 

 the nerve-cells are pathognomonic if taken in connection with 

 the clinical manifestations of the disease. The ganglion-cell 

 changes consist of degeneration, chromatolysis, and even 

 total disappearance of the nuclei, a dilatation of the peri- 

 cellular space, and an invasion not only of this space, but 

 also of the nerve-cells by embryonal cells, and at the same 

 time the appearance of small corpuscles which are hyaline, 



$ 



k - ' Vr, ** :-/x - 



Fig. 131. Normal sympathetic 

 ganglion from a normal dog. 

 (Modified from Crocq.) 



Fig. 132. Sympathetic ganglion 

 of a rabbit with experimental rab- 

 ies. (Modified from Ravenel and 

 McCarthy.) 



brownish, and in parts metachromatic. Spiller* does not 

 regard the lesions as pathognomonic of rabies. 



If an accurate diagnosis of rabies can be made by a sim- 

 ple histologic examination, in cases where animals thought 

 to be mad have bitten human beings, much time can be 

 saved in beginning the Pasteur treatment, and probably a 

 number of cases saved. 



Negrif found that by staining sections of the cerebrum, 

 cerebellum, pons, basal ganglia, and sometimes even the 



* "Pathological Society of Philadelphia," March, 1901. 

 f'Soc. Med.-Chirurg. di Pavia," 24, in, 1903; "Zeitschrift fiir 

 Hygiene," etc., xun and xuv. 



