45 Acute Contagious Conjunctivitis 



liquefied, so that the growing colonies appear to be sinking into 

 the medium after thirty-six hours. The entire tube of medium 

 may eventually be liquefied. 



Upon agar-agar containing serum, grayish-white colonies 

 of small size, resembling colonies of gonococci, are formed. 

 Growth is slow. Bouillon is slowly clouded. 



Pathogenesis. The pathogenic and specific nature of 

 the diplobacillus was made clear by Morax, who produced the 

 disease in man by placing a pure culture upon the human con- 

 junctiva. 



ZUR NEDDEN'S BACILLUS. 



This bacillus was the only organism that Haupt* was able 

 to isolate from a neuroparalytic with confluent peripheral 

 ulcer ations of the cornea. It seemed to be identical with an 

 organism that zur Nedden had found previously in a case of 

 corneal ulceration in the clinic at Bonn. 



Morphology. It is a tiny bacillus, less than i u in length, 

 slightly curved, generally single, but sometimes in pairs and 

 short chains. It is not motile, has no flagella, forms no spores. 



Staining. It stains ordinarily, but not by Gram's 

 method. 



Cultivation. It is easily cultivated upon the ordinary 

 laboratory media, the cultures being without characteristic 

 peculiarities. Gelatin is not liquefied. Milk is coagulated. 

 Acid but no gas is formed in glucose media. A thick yellow- 

 ish growth appears upon potato. No indol is formed. 



Pathogenesis. Corneal ulcers were formed in a guinea- 

 pig after artificial implantation in the corneal tissue. 



MISCELLANEOUS ORGANISMS IN CONJUNCTIVITIS. 



In addition to the foregoing organisms, others not infre- 

 quently make their appearance as excitants of conjunctivitis. 

 The most frequent of these is the pneumococcus, the most 

 dangerous, the gonococcus. The former produce a severe 

 conjunctivitis, with the formation of a false membrane, the 

 latter the well-known blenorrhea and ophthalmia neonatorum. 

 Streptococci, diphtheria bacilli, staphylococci, meningococci, 

 colon bacilli, Bacillus pneumonia (Friedlander), and other 

 organisms have been found and appear to be responsible for 

 conjunctivitis. 



*" Inaugural Dissertation," Bonn, 1902. 



