Pathogenesis 491 



incubation an illness came on, the most marked symptoms 

 being pyrexia and pulmonary irritation. After two or three 

 weeks the dogs died. Postmortem examination showed 

 catarrh of the respiratory tissues with patches of broncho- 

 pneumonia. Healthy dogs contracted the disease by con- 

 tact with those suffering from the infection. Frankel* ob- 

 tained similar results. 



The differences between the Bordet-Gengou bacillus and 

 the influenza bacillus are not great. In size, mode of oc- 

 currence, grouping and staining there is much resemblance, 

 between the two. Culturally, however, they differ because 

 the influenza bacillus grows best upon hemoglobin or blood 

 agar-agar, which is less adapted for the isolation of the Bor- 

 det-Gengou bacillus than the culture-medium given for its 

 cultivation, upon which the influenza bacillus does not 

 grow well. Further, we have as differential the peculiar 

 endotoxin of the Bordet-Gengou bacillus, the successful 

 infection of dogs and monkeys with the disease resembling 

 whooping-cough, and the transmission of this infection 

 from animal to animal by natural means. 



The subject of complement deviation as a proof of the 

 specific nature of the organism is still under consideration. 

 Bordet and Gengou found that the serum of convalescent 

 patients fixed complement when applied to the bacilli; 

 Frankel and Wollstein,f that it did not. It is claimed by 

 Bordet and Gengou that the difference in results came about 

 through the employment of different culture-media in per- 

 forming the Complement fixation tests. 



* "Mtinchener med. Wochenschrift," 1908, p. 1683. 

 t "Journal of Exp. Med.," 1909, xi, 41. 



